WEKO3
アイテム
A search for causes of rising incidence of differentiated thyroid cancer in children and adolescents after chernobyl and fukushima: Comparison of the clinical features and their relevance for treatment and prognosis
http://hdl.handle.net/10069/00040863
http://hdl.handle.net/10069/00040863cc671cf5-596f-4b49-900d-9c561f179908
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IJERPH18_3444.pdf (368.1 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-09 | |||||
| タイトル | ||||||
| タイトル | A search for causes of rising incidence of differentiated thyroid cancer in children and adolescents after chernobyl and fukushima: Comparison of the clinical features and their relevance for treatment and prognosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rising incidence of thyroid cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | screening and overdiagnosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pediatric thyroid cancer after Chernobyl and Fukushima | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nitrate and thyroid carcinogenesis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Drozd, Valentina
× Drozd, Valentina× Saenko, Vladimir× Branovan, Daniel I.× Brown, Kate× Yamashita, Shunichi× Reiners, Christoph |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The incidence of differentiated thyroid cancer (DTC) is steadily increasing globally. Epidemiologists usually explain this global upsurge as the result of new diagnostic modalities, screening and overdiagnosis as well as results of lifestyle changes including obesity and comorbidity. However, there is evidence that there is a real increase of DTC incidence worldwide in all age groups. Here, we review studies on pediatric DTC after nuclear accidents in Belarus after Chernobyl and Japan after Fukushima as compared to cohorts without radiation exposure of those two countries. According to the Chernobyl data, radiation-induced DTC may be characterized by a lag time of 4–5 years until detection, a higher incidence in boys, in children of youngest age, extrathyroidal extension and distant metastases. Radiation doses to the thyroid were considerably lower by appr. two orders of magnitude in children and adolescents exposed to Fukushima as compared to Chernobyl. In DTC patients detected after Fukushima by population-based screening, most of those characteristics were not reported, which can be taken as proof against the hypothesis, that radiation is the (main) cause of those tumors. However, roughly 80% of the Fukushima cases presented with tumor stages higher than microcarcinomas pT1a and 80% with lymph node metastases pN1. Mortality rates in pediatric DTC patients are generally very low, even at higher tumor stages. However, those cases considered to be clinically relevant should be followed-up carefully after treatment because of the risk of recurrencies which is expected to be not negligible. Considering that thyroid doses from the Fukushima accident were quite small, it makes sense to assess the role of other environmental and lifestyle-related factors in thyroid carcinogenesis. Well-designed studies with assessment of radiation doses from medical procedures and exposure to confounders/modifiers from the environment as e.g., nitrate are required to quantify their combined effect on thyroid cancer risk. | |||||
| 書誌情報 |
International Journal of Environmental Research and Public Health 巻 18, 号 7, p. art. no. 3444, 発行日 2021-03-26 |
|||||
| 出版者 | ||||||
| 出版者 | MDPI | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 16604601 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/ijerph18073444 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Journal of Environmental Research and Public Health, 18 (7), art. no. 3444; 2021 | |||||
