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Role of the innate immunity signaling pathway in the pathogenesis of sjogren’s syndrome
http://hdl.handle.net/10069/00040916
http://hdl.handle.net/10069/00040916321e22e3-39ff-4a58-873c-531ec20c8027
名前 / ファイル | ライセンス | アクション |
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IJMS22_3090.pdf (839.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-09-28 | |||||
タイトル | ||||||
タイトル | Role of the innate immunity signaling pathway in the pathogenesis of sjogren’s syndrome | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | innate immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pattern-recognition receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Toll-like receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | type I interferon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | salivary gland epithelial cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Toshimasa
× Shimizu, Toshimasa× Nakamura, Hideki× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by chronic inflammation of the salivary and lacrimal glands and extra-glandular lesions. Adaptive immune response including T- and B-cell activation contributes to the development of SS. However, its pathogenesis has not yet been elucidated. In addition, several patients with SS present with the type I interferon (IFN) signature, which is the upregulation of the IFN-stimulated genes induced by type I IFN. Thus, innate immune responses including type I IFN activity are associated with SS pathogenesis. Recent studies have revealed the presence of activation pattern recognition receptors (PRRs) including Toll-like receptors, RNA sensor retinoic acid-inducible gene I and melanoma differentiation-associated gene 5, and inflammasomes in infiltrating and epithelial cells of the salivary glands among patients with SS. In addition, the activation of PRRs via the downstream pathway such as the type I IFN signature and nuclear factor kappa B can directly cause organ inflammation, and it is correlated with the activation of adaptive immune responses. Therefore, this study assessed the role of the innate immune signal pathway in the development of inflammation and immune abnormalities in SS. | |||||
書誌情報 |
International Journal of Molecular Sciences 巻 22, 号 6, p. art. no. 3090, 発行日 2021-03-17 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1422-0067 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms22063090 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Molecular Sciences, 22(6), art. no. 3090; 2021 |