WEKO3
アイテム
{"_buckets": {"deposit": "c9c455d0-ebb7-407e-ae8f-f899d6a72f37"}, "_deposit": {"created_by": 6, "id": "26744", "owners": [6], "pid": {"revision_id": 0, "type": "depid", "value": "26744"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00026744", "sets": ["26"]}, "author_link": ["118472", "118470", "118479", "118478", "118476", "118471", "118474", "118477", "118481", "118475", "118469", "118480", "118473"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "315", "bibliographicPageStart": "309", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "Endocrine Connections"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We have previously reported that the expression of p53-binding protein 1 (53BP1) in nuclear foci (NF), a marker reflecting DNA damage response (DDR), detected using immunofluorescence (IF) is useful to estimate the malignant potency of diverse cancers. In this prospective study, we clarified the impact of 53BP1 expression via IF as a biomarker to differentiate thyroid follicular tumors (FTs) with liquid-based cytology (LBC). A total of 183 consecutively obtained-LBC samples, which were preoperatively suspected as FTs, were analyzed. Before histological diagnosis, the type of 53BP1 immunoreactivity in LBC was classified as follows: low DDR type, one or two NF; high DDR type, three or more NF; large foci type, larger than 1.0 μm; abnormal type, intense nuclear staining. Among the 183 cases, 136 cases were postoperatively diagnosed as FTs, including adenomatous goiter (AG, n = 30), follicular adenoma (FA, n = 60), FT-uncertain malignant potency (FT-UMP, n = 18), and follicular carcinoma (FC, n = 28), and 47 cases were diagnosed as tumors other than FTs or technically inadequate materials. Total 136 FT cases were collated with the type of 53BP1 immunoreactivity in LBC. The mean incidence expressing abnormal 53BP1 expression was significantly higher in FC than FA (9.5% vs 2.6%, P-value \u003c 0.001). When adopting 4.3% as a cut-off value to distinguish FC from FA, the sensitivity, specificity, positive predictive value, and negative predictive value were 89.3, 83.3, 71.4, and 94.3%, respectively. Therefore, IF analysis of 53BP1 expression can be employed as a novel technique to diagnose FTs and to distinguish between different types of FTs using LBC.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Endocrine Connections, 10(3), pp. 309-315; 2021", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Bioscientifica Ltd"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1530/EC-20-0630", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2021 The authors. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons https://doi.org/10.1530/EC-20-0630 Attribution-NonCommercial 4.0 International License."}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2049-3614", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sato, Ayako"}], "nameIdentifiers": [{"nameIdentifier": "118469", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda, Katsuya"}], "nameIdentifiers": [{"nameIdentifier": "118470", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Motoyama, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "118471", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mussazhanova, Zhanna"}], "nameIdentifiers": [{"nameIdentifier": "118472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Otsubo, Ryota"}], "nameIdentifiers": [{"nameIdentifier": "118473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Hisayoshi"}], "nameIdentifiers": [{"nameIdentifier": "118474", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akazawa, Yuko"}], "nameIdentifiers": [{"nameIdentifier": "118475", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Miyoko"}], "nameIdentifiers": [{"nameIdentifier": "118476", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Ayana"}], "nameIdentifiers": [{"nameIdentifier": "118477", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirokawa, Mitsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "118478", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyauchi, Akira"}], "nameIdentifiers": [{"nameIdentifier": "118479", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagayasu, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "118480", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "118481", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-09-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "EndCon10_309.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "EndCon10_309.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/26744/files/EndCon10_309.pdf"}, "version_id": "fd8798e0-c116-411c-8dab-af3aa0aeb088"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "53BP1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "genomic instability", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunofluorescence", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thyroid follicular tumor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liquid-based cytology", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "53BP1 expression as a biomarker to differentiate thyroid follicular tumors", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "53BP1 expression as a biomarker to differentiate thyroid follicular tumors"}]}, "item_type_id": "2", "owner": "6", "path": ["26"], "permalink_uri": "http://hdl.handle.net/10069/00040918", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-09-29"}, "publish_date": "2021-09-29", "publish_status": "0", "recid": "26744", "relation": {}, "relation_version_is_last": true, "title": ["53BP1 expression as a biomarker to differentiate thyroid follicular tumors"], "weko_shared_id": -1}
53BP1 expression as a biomarker to differentiate thyroid follicular tumors
http://hdl.handle.net/10069/00040918
http://hdl.handle.net/10069/000409188af0be95-2f1a-4794-ac6f-24978673d6d7
名前 / ファイル | ライセンス | アクション |
---|---|---|
EndCon10_309.pdf (2.4 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-09-29 | |||||
タイトル | ||||||
タイトル | 53BP1 expression as a biomarker to differentiate thyroid follicular tumors | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 53BP1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genomic instability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunofluorescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid follicular tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liquid-based cytology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sato, Ayako
× Sato, Ayako× Matsuda, Katsuya× Motoyama, Takahiro× Mussazhanova, Zhanna× Otsubo, Ryota× Kondo, Hisayoshi× Akazawa, Yuko× Higuchi, Miyoko× Suzuki, Ayana× Hirokawa, Mitsuyoshi× Miyauchi, Akira× Nagayasu, Takeshi× Nakashima, Masahiro |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have previously reported that the expression of p53-binding protein 1 (53BP1) in nuclear foci (NF), a marker reflecting DNA damage response (DDR), detected using immunofluorescence (IF) is useful to estimate the malignant potency of diverse cancers. In this prospective study, we clarified the impact of 53BP1 expression via IF as a biomarker to differentiate thyroid follicular tumors (FTs) with liquid-based cytology (LBC). A total of 183 consecutively obtained-LBC samples, which were preoperatively suspected as FTs, were analyzed. Before histological diagnosis, the type of 53BP1 immunoreactivity in LBC was classified as follows: low DDR type, one or two NF; high DDR type, three or more NF; large foci type, larger than 1.0 μm; abnormal type, intense nuclear staining. Among the 183 cases, 136 cases were postoperatively diagnosed as FTs, including adenomatous goiter (AG, n = 30), follicular adenoma (FA, n = 60), FT-uncertain malignant potency (FT-UMP, n = 18), and follicular carcinoma (FC, n = 28), and 47 cases were diagnosed as tumors other than FTs or technically inadequate materials. Total 136 FT cases were collated with the type of 53BP1 immunoreactivity in LBC. The mean incidence expressing abnormal 53BP1 expression was significantly higher in FC than FA (9.5% vs 2.6%, P-value < 0.001). When adopting 4.3% as a cut-off value to distinguish FC from FA, the sensitivity, specificity, positive predictive value, and negative predictive value were 89.3, 83.3, 71.4, and 94.3%, respectively. Therefore, IF analysis of 53BP1 expression can be employed as a novel technique to diagnose FTs and to distinguish between different types of FTs using LBC. | |||||
書誌情報 |
Endocrine Connections 巻 10, 号 3, p. 309-315, 発行日 2021-03 |
|||||
出版者 | ||||||
出版者 | Bioscientifica Ltd | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2049-3614 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1530/EC-20-0630 | |||||
権利 | ||||||
権利情報 | © 2021 The authors. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons https://doi.org/10.1530/EC-20-0630 Attribution-NonCommercial 4.0 International License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Endocrine Connections, 10(3), pp. 309-315; 2021 |