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Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus
http://hdl.handle.net/10069/00040999
http://hdl.handle.net/10069/0004099913c0280f-167a-4e9d-b26c-3e126e4a2b18
名前 / ファイル | ライセンス | アクション |
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Viruses13_869.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-04 | |||||
タイトル | ||||||
タイトル | Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | severe fever with thrombocytopenia syndrome virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiviral | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | loperamide | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Urata, Shuzo
× Urata, Shuzo× Yasuda, Jiro× Iwasaki, Masaharu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia. It has a mortality rate of up to 30%, and there is no approved treatment against the disease. In this study, we evaluated the effect of loperamide, an antidiarrheal and antihyperalgesic agent, on the propagation of SFTSV in a cell culture system. Methods: SFTSV-infected human cell lines were exposed to loperamide, and viral titers were evaluated. To clarify the mode of action of loperamide, several chemical compounds having shared targets with loperamide were used. Calcium imaging was also performed to understand whether loperamide treatment affected calcium influx. Results: Loperamide inhibited SFTSV propagation in several cell lines. It inhibited SFTSV in the post-entry step and restricted calcium influx into the cell. Furthermore, nifedipine, a calcium channel inhibitor, also blocked post-entry step of SFTSV infection. Conclusions: Loperamide inhibits SFTSV propagation mainly by restraining calcium influx into the cytoplasm. This indicates that loperamide, a Food and Drug Administration (FDA)-approved drug, has the potential for being used as a treatment option against SFTS. |
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書誌情報 |
Viruses 巻 13, 号 5, p. art. no. 869, 発行日 2021-05-10 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19994915 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/v13050869 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Viruses, 13(5), art. no. 869; 2021 |