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Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
http://hdl.handle.net/10069/37906
http://hdl.handle.net/10069/379060688cc36-6a91-41f6-8304-c455a510e8b7
名前 / ファイル | ライセンス | アクション |
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TMH45_32.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-11-28 | |||||
タイトル | ||||||
タイトル | Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dengue virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antiviral | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brefeldin A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Secondary metabolite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fungus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Raekiansyah, Muhareva
× Raekiansyah, Muhareva× Mori, Mihoko× Nonaka, Kenichi× Agoh, Masanobu× Shiomi, Kazuro× Matsumoto, Atsuko× Morita, Kouichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery. | |||||
書誌情報 |
Tropical Medicine and Health 巻 45, p. 32, 発行日 2017-10-26 |
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出版者 | ||||||
出版者 | BioMed Central Ltd. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s41182-017-0072-7 | |||||
権利 | ||||||
権利情報 | c The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health, 45, 32; 2017 |