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However, the most suitable time to initiate treatment in septic shock patients with IFI is unknown.\nMethods: Patients with septic shock treated with L-AMB were identified from the Japanese Diagnosis Procedure Combination national database and were stratified according to L-AMB treatment initiation either at septic shock onset (early L-AMB group) or after the onset (delayed L-AMB group) to determine their survival rates following septic shock onset and the shock cessation period.\nResults: We identified 141 patients administered L-AMB on the day of or after septic shock onset: 60 patients received early treatment, whereas 81 patients received delayed treatment. Survival rates after septic shock onset were higher in the early L-AMB group than in the delayed L-AMB group (4 weeks: 68.4% vs 57.9%, P = 0.197; 6 weeks: 62.2% vs 44.5%, P = 0.061; 12 weeks: 43.4% vs 35.0%, P = 0.168, respectively). 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Efficacy of early administration of liposomal amphotericin B in patients with septic shock: A nationwide observational study
http://hdl.handle.net/10069/00041011
http://hdl.handle.net/10069/0004101174a45494-174c-4a05-8d5d-ed796e85f6e0
名前 / ファイル | ライセンス | アクション |
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JIC27_1471.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-09 | |||||
タイトル | ||||||
タイトル | Efficacy of early administration of liposomal amphotericin B in patients with septic shock: A nationwide observational study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liposomal amphotericin B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mortality | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Septic shock | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Early administration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Observational study | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tashiro, Masato
× Tashiro, Masato× Takazono, Takahiro× Ota, Yuki× Wakamura, Tomotaro× Takahashi, Akinori× Sato, Kumiko× Miyazaki, Taiga× Obata, Yoko× Nishino, Tomoya× Izumikawa, Koichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Liposomal amphotericin B (L-AMB), a broad spectrum anti-fungicidal drug, is often administered to treat invasive fungal infections (IFIs). However, the most suitable time to initiate treatment in septic shock patients with IFI is unknown. Methods: Patients with septic shock treated with L-AMB were identified from the Japanese Diagnosis Procedure Combination national database and were stratified according to L-AMB treatment initiation either at septic shock onset (early L-AMB group) or after the onset (delayed L-AMB group) to determine their survival rates following septic shock onset and the shock cessation period. Results: We identified 141 patients administered L-AMB on the day of or after septic shock onset: 60 patients received early treatment, whereas 81 patients received delayed treatment. Survival rates after septic shock onset were higher in the early L-AMB group than in the delayed L-AMB group (4 weeks: 68.4% vs 57.9%, P = 0.197; 6 weeks: 62.2% vs 44.5%, P = 0.061; 12 weeks: 43.4% vs 35.0%, P = 0.168, respectively). The septic shock cessation period was shorter in the early L-AMB group than in the delayed L-AMB group (7.0 ± 7.0 days vs 16.5 ± 15.4 days, P < 0.001), with a significant difference confirmed after adjusting for confounding factors with propensity score matching (7.1 ± 7.2 days vs 16.7 ± 14.0 days, P = 0.001). Conclusion: Early L-AMB administration at septic shock onset may be associated with early shock cessation. |
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書誌情報 |
Journal of Infection and Chemotherapy 巻 27, 号 10, p. 1471-1476, 発行日 2021-06-26 |
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出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jiac.2021.06.013 | |||||
権利 | ||||||
権利情報 | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Infection and Chemotherapy, 27 (10), pp. 1471-1476; 2021 |