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Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins
http://hdl.handle.net/10069/00041193
http://hdl.handle.net/10069/0004119350a12d16-deba-4520-9953-e014ed14e69a
名前 / ファイル | ライセンス | アクション |
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FCDB9_749153.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-01-28 | |||||
タイトル | ||||||
タイトル | Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | plasmodium falciparum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholesterol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipoproteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | exosomes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | scavenger receptors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Iso-o, Naoyuki
× Iso-o, Naoyuki× Komatsuya, Keisuke× Tokumasu, Fuyuki× Isoo, Noriko× Ishigaki, Tomohiro× Yasui, Hiroshi× Yotsuyanagi, Hiroshi× Hara, Masumi× Kita, Kiyoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Malaria parasites cannot multiply in host erythrocytes without cholesterol because they lack complete sterol biosynthesis systems. This suggests parasitized red blood cells (pRBCs) need to capture host sterols, but its mechanism remains unknown. Here we identified a novel high-density lipoprotein (HDL)-delivery pathway operating in blood-stage Plasmodium. In parasitized mouse plasma, exosomes positive for scavenger receptor CD36 and platelet-specific CD41 increased. These CDs were detected in pRBCs and internal parasites. A low molecular antagonist for scavenger receptors, BLT-1, blocked HDL uptake to pRBCs and suppressed Plasmodium growth in vitro. Furthermore, platelet-derived exosomes were internalized in pRBCs. Thus, we presume CD36 is delivered to malaria parasites from platelets by exosomes, which enables parasites to steal HDL for cholesterol supply. Cholesterol needs to cross three membranes (RBC, parasitophorous vacuole and parasite’s plasma membranes) to reach parasite, but our findings can explain the first step of sterol uptake by intracellular parasites. | |||||
書誌情報 |
Frontiers in Cell and Developmental Biology 巻 9, p. 749153, 発行日 2021-11-11 |
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出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2296-634X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fcell.2021.749153 | |||||
権利 | ||||||
権利情報 | © 2021 Iso-o, Komatsuya, Tokumasu, Isoo, Ishigaki, Yasui, Yotsuyanagi, Hara and Kita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Frontiers in Cell and Developmental Biology, 9, art. no. 749153; 2021 |