WEKO3
アイテム
{"_buckets": {"deposit": "ac075dd9-3829-4170-b1b7-a55f5f507bcf"}, "_deposit": {"created_by": 6, "id": "27030", "owners": [6], "pid": {"revision_id": 0, "type": "depid", "value": "27030"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00027030", "sets": ["11"]}, "author_link": ["120357", "120359", "120356", "120355", "120358"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-11-22", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageStart": "1739", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{"bibliographic_title": "Biomedicines"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is known to be involved in hypothalamic appetite and adipose tissue inflammation and metabolism. In this study, the NPY−/− mice showed a marked decrease in body weight and adiposity, and lower free fatty acid and adipose inflammation without food intake alteration during a high fat diet (HFD). Moreover, NPY deficiency increased the thermogenic genes expression in brown adipose tissue. Notably, NPY-mRNA expression was upregulated in macrophages from the HFD mice compared to that from the mice on a standard diet. The NPY-mRNA expression also positively correlated with the liver mass/body weight ratio. NPY deletion alleviated HFD-induced adipose inflammation and liver steatosis. Hence, our findings point toward a novel intracellular mechanism of NPY in the regulation of adipocyte-macrophage crosstalk and highlight NPY antagonism as a promising target for therapeutic approaches against obesity and NAFLD.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Biomedicines, 9(11), art. no. 1739; 2021", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/biomedicines9111739", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2227-9059", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Park, Seongjoon"}], "nameIdentifiers": [{"nameIdentifier": "120355", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Toshimitsu"}], "nameIdentifiers": [{"nameIdentifier": "120356", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Hiroko"}], "nameIdentifiers": [{"nameIdentifier": "120357", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Ryoichi"}], "nameIdentifiers": [{"nameIdentifier": "120358", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimokawa, Isao"}], "nameIdentifiers": [{"nameIdentifier": "120359", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-01-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Biomedicines9_1739.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "Biomedicines9_1739.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/27030/files/Biomedicines9_1739.pdf"}, "version_id": "1cd25e79-5817-40a9-9ae4-c5a914a06409"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "obesity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fatty liver", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neuropeptide Y", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "brown adipose tissue", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis"}]}, "item_type_id": "2", "owner": "6", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/00041194", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-01-28"}, "publish_date": "2022-01-28", "publish_status": "0", "recid": "27030", "relation": {}, "relation_version_is_last": true, "title": ["The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis"], "weko_shared_id": -1}
The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
http://hdl.handle.net/10069/00041194
http://hdl.handle.net/10069/0004119457194ef7-05a4-4f64-8077-1fb276e52568
名前 / ファイル | ライセンス | アクション |
---|---|---|
Biomedicines9_1739.pdf (2.4 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-01-28 | |||||
タイトル | ||||||
タイトル | The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | obesity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fatty liver | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuropeptide Y | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brown adipose tissue | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Park, Seongjoon
× Park, Seongjoon× Komatsu, Toshimitsu× Hayashi, Hiroko× Mori, Ryoichi× Shimokawa, Isao |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is known to be involved in hypothalamic appetite and adipose tissue inflammation and metabolism. In this study, the NPY−/− mice showed a marked decrease in body weight and adiposity, and lower free fatty acid and adipose inflammation without food intake alteration during a high fat diet (HFD). Moreover, NPY deficiency increased the thermogenic genes expression in brown adipose tissue. Notably, NPY-mRNA expression was upregulated in macrophages from the HFD mice compared to that from the mice on a standard diet. The NPY-mRNA expression also positively correlated with the liver mass/body weight ratio. NPY deletion alleviated HFD-induced adipose inflammation and liver steatosis. Hence, our findings point toward a novel intracellular mechanism of NPY in the regulation of adipocyte-macrophage crosstalk and highlight NPY antagonism as a promising target for therapeutic approaches against obesity and NAFLD. | |||||
書誌情報 |
Biomedicines 巻 9, 号 11, p. 1739, 発行日 2021-11-22 |
|||||
出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2227-9059 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/biomedicines9111739 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomedicines, 9(11), art. no. 1739; 2021 |