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Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren’s Syndrome Patients
http://hdl.handle.net/10069/00041238
http://hdl.handle.net/10069/000412382d6f9068-a6ab-4ac1-9d28-2e310891d3e8
名前 / ファイル | ライセンス | アクション |
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AIMM29_734.pdf (678.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-02-08 | |||||
タイトル | ||||||
タイトル | Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren’s Syndrome Patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | long noncoding RNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nuclear factor of activated T cells (NFAT)c1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NRON | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proviral integration site for Moloney murine leukemia virus (PIM)-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sjögren’s syndrome | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Horai, Yoshiro
× Horai, Yoshiro× Nakamura, Hideki× Shimizu, Toshimasa× Nishihata, Shinya× Iwamoto, Naoki× Kuroki, Tamotsu× Okano, Shinji× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of our study was to analyze the expressions of nuclear factor of activated T cells (NFAT)-related substances including long noncoding RNA NRON which participates in pathophysiology of Sjögren’s syndrome (SS), and to assess the histologic findings in individuals with SS. In this study, the expressions of NRON, NFATc1, CD3/CD4, and proviral integration site for Moloney murine leukemia virus (PIM)-1 were examined by in situ hybridization, immunohistochemical analysis, and immunofluorescence in labial salivary glands (LSGs) obtained from 16 patients with SS and five controls. The microcell count method has been applied to calculate the NFATc1-positive area/infiltrating cell area in LSGs, and we compared those results to the infiltrating cell area, focus score, serum immunoglobulin G, and the European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index. The NRON expression in the nuclei of cell-infiltration lesions of the SS patients were prominent. The NFATc1 expression was strong in the cytoplasm of infiltrating mononuclear cells and weak in ducts of both SS and controls. In SS, the NFATc1-positive area/infiltrating cell area was positively correlated with the infiltrating cell area and focus score. CD3/CD4 was expressed in infiltrating mononuclear cells, and PIM-1 colocalized with NFATc1 in the cytoplasm. These results suggest NRON along with NFATc1/PIM-1 in SS LSGs might participate in SS pathophysiology. | |||||
書誌情報 |
Applied Immunohistochemistry & Molecular Morphology 巻 29, 号 10, p. 734-740, 発行日 2021-12 |
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出版者 | ||||||
出版者 | Wolters Kluwer Health, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1541-2016 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/PAI.0000000000000959 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Applied immunohistochemistry & molecular morphology, 29(10), pp. 734-740; 2021 |