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Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019
http://hdl.handle.net/10069/00041252
http://hdl.handle.net/10069/00041252d5a1eb0d-c306-46a3-8251-3dc693afb36b
名前 / ファイル | ライセンス | アクション |
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ISYK1369_Aung.pdf (3.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2022-02-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dengue outbreak | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myanmar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | co-circulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serotypes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genotype-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DENV-3 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
AUNG, MIN SOE
× AUNG, MIN SOE |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1–4 demonstrated that most DENV-1–4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1369号 学位授与年月日:令和3年9月17日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Aung Min Soe, Mya Myat Ngwe Tun, Takeshi Nabeshima, Theingi Win Myat, Moh Moh Htun, Htin Lin, Nang Sarm Hom, Shingo Inoue, Khine Mya Nwe, Lynn Pa Pa Aye, Mizuki Fukuta, Kyaw Zin Thant, Futoshi Hasebe, Kouichi Morita, Sujan Shresta, Hlaing Myat Thu, Meng Ling Moi | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Viruses, 13(6), 1152; 2021 | |||||
書誌情報 |
Viruses 巻 13, 号 6, p. 1152, 発行日 2021-09-17 |
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EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1999-4915 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/v13061152 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | ミャンマー・ヤンゴン市におけるデング3型ウイルス(DENV-3)遺伝子型Iの出現に伴うDENV-3症例の増加、2017年-2019年 | |||||
出版者 | ||||||
出版者 | MDPI | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/00040956 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2021-09-17 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1369号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2021-09-17) |