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The seroprevalence, waning rate, and protective duration of anti-diphtheria toxoid IgG antibody in Nha Trang, Vietnam
http://hdl.handle.net/10069/00041303
http://hdl.handle.net/10069/00041303f8b62f47-50ec-4ad0-ab37-b204f30354ff
名前 / ファイル | ライセンス | アクション |
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IJID116_273.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-03-08 | |||||
タイトル | ||||||
タイトル | The seroprevalence, waning rate, and protective duration of anti-diphtheria toxoid IgG antibody in Nha Trang, Vietnam | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diphtheria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | schedule | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DTP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vietnam | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kitamura, Noriko
× Kitamura, Noriko× Le, Lien Thuy× Le, Thao Thi Thu× Nguyen, Hien-Anh Thi× Edwards, Tansy× Madaniyazi, Lina× Bui, Minh Xuan× Do, Hung Thai× Dang, Duc-Anh× Toizumi, Michiko× Fine, Paul× Yoshida, Lay-Myint |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Diphtheria cases reported in Central Vietnam since 2013 were mainly in children aged 6-15 years, which may reflect an immunity gap. There is little information on population immunity against diphtheria in countries without a school-entry booster dose. We aimed to measure the age-stratified seroprevalence of anti-diphtheria toxoid antibodies, quantify the change in antibody levels in individuals over time, and estimate the length of protective immunity after vaccination in well-vaccinated communities in Vietnam. Methods: An age-stratified seroprevalence survey among individuals aged 0-55 years was conducted at Nha Trang, Vietnam. The same participants were followed up after two years to quantify the change in antibody levels. IgG was measured using ELISA. The length of protective immunity after vaccination was estimated using a mixed-effect linear regression model with random intercept. Results: Overall seroprevalence was 26% (95%CI:20-32%). Age-stratified seroprevalence was 68% (95%CI:4-11%), 7% (95%CI:4-11%), 12% (95%CI:7-19%), 33% (95%CI:27-40%), and 28% (95%CI:17-43%) among those aged ≤5, 6-15,16-25, 26-35, and 36-55 years, respectively. The antibody levels declined by 47% (95%CI:31-59%) over two years, and the predicted duration of vaccine-derived protective immunity after receiving four doses was 4.3 years (95%CI:3.5–5.3) among participants aged six years or younger. Conclusion: Given the low seroprevalence and short period of vaccine protection, a school-entry booster dose (5-7 years) is recommended in Vietnam. |
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書誌情報 |
International Journal of Infectious Diseases 巻 116, p. 273-280, 発行日 2022-01-19 |
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出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 12019712 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijid.2022.01.025 | |||||
権利 | ||||||
権利情報 | © 2022 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Infectious Diseases, 116, pp. 273-280; 2022 |