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An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey
http://hdl.handle.net/10069/37943
http://hdl.handle.net/10069/37943e77245fa-de92-4d21-9d4a-bc0d0a5e04d6
名前 / ファイル | ライセンス | アクション |
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JID70_621.pdf (380.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-30 | |||||
タイトル | ||||||
タイトル | An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human immunodeficiency virus (HIV) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | high-risk group | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | risk behavior | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiretroviral drug resistance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Do, Hung Thai
× Do, Hung Thai× Nguyen, Dong Thanh× Nguyen, Lan Anh Thi× Do, Duong Huy× Le, Huy Xuan× Trinh, Xuan Mai Thi× Ton, Hong Vy Nu× Sawada, Ikumi× Kitamura, Noriko× Le, Minh Nhat× Yoshihara, Keisuke× Phan, Thu Huong Thi× Bui, Chien Trong× Ariyoshi, Koya× Yoshida, Lay Myint |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We studied the prevalence of HIV drug resistance among high-risk groups such as injecting drug users (IDUs), female sex workers (FSWs), and men having sex with men (MSM) in central Vietnam. We used HIV-positive blood samples from 2012?2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays, and the HIV-positive samples were further tested for HIV viral load and drug-resistance mutations (DRMs) by in-house assays. DRMs were identified using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 (high-risk) subjects were screened, and 97 tested positive for HIV infection (IDUs: n = 63, 3.0%; FSWs: n = 24, 0.9%; and MSM: n = 10, 1.0%). Ninety-two of the 97 samples (45 from 2012 and 47 from 2013) were available for further testing. HIV RNA was detected in 56 (60.9%) of the 92 samples, and drug resistance genotyping was successfully performed on 40 (71.4%) samples. All these isolates were subtype CRF01_AE, except for 1 (2.5%) IDU whose HIV belongs to subtype B. Thirteen individuals (32.5%) were carrying HIV with at least 1 DRM: 9 IDUs, 1 FSW, and 3 MSM. Thus, HIV seroprevalence among high-risk individuals in central Vietnam is low, but a high proportion of drug resistant HIV-1 isolates is observed in the high-risk group. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 70, 号 6, p. 621-627, 発行日 2017-11-22 |
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出版者 | ||||||
出版者 | 国立感染症研究所 | |||||
出版者別言語 | ||||||
National Institute of Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18842836 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.JJID.2016.512 | |||||
権利 | ||||||
権利情報 | c 2017 National Institute of Infectious Diseases | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 70(6), pp.621-627; 2017 |