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Divergent Total Synthesis of Azalamellarins D and N
http://hdl.handle.net/10069/00041475
http://hdl.handle.net/10069/00041475d0b705fb-5c50-4190-b0fb-1c18eb7c638e
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Het103_862.pdf (1.4 MB)
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Het103_862_SI.pdf (4.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-25 | |||||
タイトル | ||||||
タイトル | Divergent Total Synthesis of Azalamellarins D and N | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fukuda, Tsutomu
× Fukuda, Tsutomu× Okutani, Seiya× Sumi, Mayu× Miyagi, Kazuhito× Onodera, Gen× Kimura, Masanari |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lamellarins are polycyclic marine alkaloids with potent cytotoxic activities against cancer cell lines. A divergent synthesis of azalamellarins D and N, lactam congeners of the marine natural products lamellarins D and N, has been achieved via the pentacyclic 14-bromo-8,9-dihydro-benzo[7,8]indolizino[3,2-c]- quinolin-6(5H)-one intermediate. The pentacyclic intermediate can be synthesized from methyl 1-(benzensulfonyl)-3-bromo-1H-pyrrole-2-carboxylate via the Suzuki–Miyaura cross-coupling and intramolecular direct arylation as key reactions. | |||||
書誌情報 |
HETEROCYCLES 巻 103, 号 2, p. 862-877, 発行日 2021-02-08 |
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出版者 | ||||||
出版者 | 日本複素環化学研究所 | |||||
出版者別言語 | ||||||
Japan Institute of Heterocyclic Chemistry | ||||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1881-0942 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3987/COM-20-S(K)53 | |||||
権利 | ||||||
権利情報 | ©2021 the Japan Institute of Heterocyclic Chemistry | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Heterocycles, 103 (2), pp862-877; 2021 |