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Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study
http://hdl.handle.net/10069/00041484
http://hdl.handle.net/10069/000414843d9c0757-4610-4d31-a56e-4439de32f890
名前 / ファイル | ライセンス | アクション |
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Bone160_116416.pdf (3.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-28 | |||||
タイトル | ||||||
タイトル | Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Teriparatide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Weekly teriparatide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High-dose teriparatide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High-resolution peripheral quantitative | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | computed tomography (HR-pQCT) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone microarchite | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chiba, Ko
× Chiba, Ko× Okazaki, Narihiro× Kurogi, Ayako× Watanabe, Tsuyoshi× Mori, Ai× Suzuki, Nobuhiko× Adachi, Koichi× Era, Makoto× Yokota, Kazuaki× Inoue, Takuma× Yabe, Yoshihiro× Furukawa, Keizo× Kondo, Choko× Tsuda, Keiichi× Ota, Shingo× Isobe, Yusaku× Miyazaki, Satsuki× Morimoto, Shimpei× Sato, Shuntaro× Nakashima, Sawako× Tashiro, Shigeki× Yonekura, Akihiko× Tomita, Masato× Osaki, Makoto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: The effects of daily teriparatide (20 μg) (D-PTH), weekly high-dose teriparatide (56.5 μg) (W-PTH), or bisphosphonates (BPs) on areal bone mineral density (aBMD), bone turnover markers (BTMs), volumetric BMD (vBMD), microarchitecture, and estimated strength were investigated in postmenopausal osteoporosis patients. Methods: The study participants were 131 women with a history of fragility fractures. They were randomized to receive D-PTH, W-PTH, or BPs (alendronate or risedronate) for 18 months. Dual-energy X-ray absorptiometry (DXA), BTMs, and high-resolution peripheral quantitative CT (HR-pQCT) parameters were evaluated at baseline and after 6 and 18 months of treatment. The primary endpoint was the change (%) in cortical thickness (Ct.Th) after 18 months' treatment compared with baseline. Results: DXA showed that D-PTH, W-PTH, and BPs increased lumbar spine aBMD (+12.0%, +8.5%, and +6.8%) and total hip aBMD (+3.0%, +2.1%, and +3.0%), but D-PTH and W-PTH decreased 1/3 radius aBMD (− 4.1%, − 3.0%, − 1.4%) after 18 months. On HR-pQCT, D-PTH increased trabecular vBMD (Tb.vBMD) at the distal radius and tibia after 18 months (+6.4%, +3.7%) compared with the BPs group, decreased cortical volumetric tissue mineral density (Ct.vTMD) (− 1.8%, − 0.9%) compared with the other groups, increased Ct.Th (+1.3%, +3.9%), and increased failure load (FL) (+4.7%, +4.4%). W-PTH increased Tb.vBMD (+5.3%, +1.9%), maintained Ct.vTMD (− 0.7%, +0.2%) compared with D-PTH, increased Ct.Th (+0.6%, +3.6%), and increased FL (+4.9%, +4.5%). The BPs increased Tb.vBMD only in the radius (+2.0%, +0.2%), maintained Ct.vTMD (− 0.6%, +0.3%), increased Ct.Th (+0.5%, +3.4%), and increased FL (+3.9%, +2.8%). Conclusions: D-PTH and W-PTH comparably increased Ct.Th, the primary endpoint. D-PTH had a strong effect on trabecular bone. Although D-PTH decreased Ct.vTMD, it increased Ct.Th and total bone strength. W-PTH had a moderate effect on trabecular bone, maintained Ct.vTMD, and increased Ct.Th and total bone strength to the same extent as D-PTH. |
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書誌情報 |
Bone 巻 160, p. 116416, 発行日 2022-04-06 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 87563282 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bone.2022.116416 | |||||
権利 | ||||||
権利情報 | © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone, 160, art. no. 116416; 2022 |