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Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy
http://hdl.handle.net/10069/00041563
http://hdl.handle.net/10069/00041563acd90b41-d857-4c72-af5c-ea266062c04e
名前 / ファイル | ライセンス | アクション |
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ISYK1444_Honda.pdf (387.1 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2022-05-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corpus callosotomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Developmental outcome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Seizure outcome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Infants and young children | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug-resistant epilepsy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
本田, 涼子
× 本田, 涼子 |
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著者別名 | ||||||
姓名 | Honda, Ryoko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood. Methods: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients’ developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale. Results: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was −1.6 points (SD, 11.6). However, 42.5% of patients had a mean DQ increase of 6.5 points (SD, 6.4), one year after CC from that before surgery. Factors related to the improvement in postoperative DQ were ‘low preoperative DQ’, ‘developmental gain 1 month postoperatively’, and ‘postoperative seizure-free state’. Approximately 21.7% of patients were seizure-free 1 year after CC. Interpretation: Performing CC, in infancy and early childhood for patients with drug-resistant epilepsy and severe developmental impairment, was associated with improved development in 42.5% of patients. Remission of seizures, even if only for a short period, contributed to developmental improvement. From a developmental perspective, CC for drug-resistant epilepsy in early childhood is an effective treatment. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1444号 学位授与年月日:令和4年3月18日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Ryoko Honda, Hiroshi Baba, Kohei Adachi, Rika Koshimoto, Tomonori Ono, Keisuke Toda, Shigeki Tanaka, Shiro Baba, Kazumi Yamasaki, Hiroshi Yatsuhashi | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Epilepsy & Behavior, 117, art. no. 107799; 2021 | |||||
書誌情報 |
Epilepsy & Behavior 巻 117, p. 107799, 発行日 2022-03-18 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1525-5050 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.yebeh.2021.107799 | |||||
権利 | ||||||
権利情報 | © 2021 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 乳幼児の薬剤抵抗性てんかんに対する脳梁離断術後の発達予後 | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/00041447 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2022-03-18 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1444号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2022-03-18) |