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Materials and Methods: Using automatically quantified iodine mapping in dual-energy computed tomography, we evaluated lung relative average enhancement, standard deviation (SD), and the SD/lung relative average enhancement ratio. We compared the values for these parameters in normal patients versus those with CTEPH. We also performed a receiver operating characteristic curve analysis to determine the diagnostic cutoffs for the parameters. Results: Patients constituted 41 patients (10 male [24.4%] and 31 female [75.6%]; mean age [SD]: 70.0 y [13.3]) with CTEPH and 237 (92 male [38.8%] and 145 female [61.2%]; mean age [SD]: 65.9 y [15.9]) normal patients. We found significant differences in lung relative average enhancement (34.9±6.3 vs. 26.9±6.3; P\u003c0.0001), SD (11.6±1.9 vs. 14.7±3.3; P\u003c0.001), and the SD/lung relative average enhancement ratio (33.7±5.0 vs. 55.7±10.4; P\u003c0.001) between the normal and CTEPH groups, respectively. 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Diagnosis of Chronic Thromboembolic Pulmonary Hypertension Using Quantitative Lung Perfusion Parameters Extracted From Dual-energy Computed Tomography Images
http://hdl.handle.net/10069/00041631
http://hdl.handle.net/10069/00041631790a0d10-46b4-4624-bbb5-935e54f136f9
名前 / ファイル | ライセンス | アクション |
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JTI374_239.pdf (777.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-19 | |||||
タイトル | ||||||
タイトル | Diagnosis of Chronic Thromboembolic Pulmonary Hypertension Using Quantitative Lung Perfusion Parameters Extracted From Dual-energy Computed Tomography Images | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic thromboembolic pulmonary hypertension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dual-energy computed tomography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lung relative average enhancement | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | standard deviation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Koike, Hirofumi
× Koike, Hirofumi× Sueyoshi, Eijun× Uetani, Masataka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To evaluate quantified iodine mapping parameters in dual-energy computed tomography in normal patients versus those with chronic thromboembolic pulmonary hypertension (CTEPH) with and without pulmonary thromboembolism. Materials and Methods: Using automatically quantified iodine mapping in dual-energy computed tomography, we evaluated lung relative average enhancement, standard deviation (SD), and the SD/lung relative average enhancement ratio. We compared the values for these parameters in normal patients versus those with CTEPH. We also performed a receiver operating characteristic curve analysis to determine the diagnostic cutoffs for the parameters. Results: Patients constituted 41 patients (10 male [24.4%] and 31 female [75.6%]; mean age [SD]: 70.0 y [13.3]) with CTEPH and 237 (92 male [38.8%] and 145 female [61.2%]; mean age [SD]: 65.9 y [15.9]) normal patients. We found significant differences in lung relative average enhancement (34.9±6.3 vs. 26.9±6.3; P<0.0001), SD (11.6±1.9 vs. 14.7±3.3; P<0.001), and the SD/lung relative average enhancement ratio (33.7±5.0 vs. 55.7±10.4; P<0.001) between the normal and CTEPH groups, respectively. The ROC analyses demonstrated high discriminatory power (area under the curve=0.99) for using the SD/lung relative average enhancement ratio to differentiate between patients in the normal group and CTEPH group. At a threshold for the area under the curve of 44.2, diagnostic sensitivity, specificity, positive predictive value, and negative predictive value for the ratio were 92.7%, 97.5%, 86.5%, and 98.7%, respectively. Conclusions: Patients with CTEPH were well-discriminated from normal patients using the SD/lung relative average enhancement ratio. | |||||
書誌情報 |
Journal of Thoracic Imaging 巻 37, 号 4, p. 239-245, 発行日 2022-07 |
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出版者 | ||||||
出版者 | Wolters Kluwer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0883-5993 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/RTI.0000000000000646 | |||||
権利 | ||||||
権利情報 | © 2022 Wolters Kluwer Health, Inc.This is a non-final version of an article published in final form in (provide complete journal citation) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Thoracic Imaging, 37(4), pp. 239-245; 2022 |