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One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin
http://hdl.handle.net/10069/37987
http://hdl.handle.net/10069/37987c563844a-a9aa-4b7f-bcad-9942bbbcbf11
名前 / ファイル | ライセンス | アクション |
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JDT25_704.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-05-02 | |||||
タイトル | ||||||
タイトル | One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Doxorubicin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | curcumin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polyacrylic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calcium carbonate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid nanoparticle | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Peng, Jianqing
× Peng, Jianqing× Fumoto, Shintaro× Miyamoto, Hirotaka× Chen, Yi× Kuroda, Naotaka× Nishida, Koyo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of the different water-solubility of these drugs. This study provides a strategy for the “one-step” formation of nanoparticles encapsulating both Dox and Cur. We took advantage of polyacrylic acid (PAA) and calcium carbonate (CaCO3) to realise a high drug entrapment efficiency (EE) and pH-sensitive drug release using a simplified preparation method. Optimisation of lipid ratios and concentrations of CaCO3 was conducted. Under optimal conditions, the mean diameter of PEGylated lipid/PAA/CaCO3 nanoparticles with encapsulated Cur and Dox (LPCCD) was less than 100?nm. An obvious pH-sensitive release of both drugs was observed, with different Dox and Cur release rates. Successful co-delivery of Cur and Dox was achieved via LPCCD on HepG2 cells. LPCCD altered the bio-distribution of Dox and Cur in vivo and decreased Dox-induced cardiotoxicity. The current investigation has developed an efficient ternary system for co-delivery of Dox and Cur to tumours, using a “one-step” formation resulting in nanoparticles possessing remarkable pH-sensitive drug release behaviour, which may be valuable for further clinical studies and eventual clinical application. | |||||
書誌情報 |
Journal of Drug Targeting 巻 25, 号 8, p. 704-714, 発行日 2017-05-02 |
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出版者 | ||||||
出版者 | Informa UK Limited | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1061186X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10292330 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/1061186X.2017.1315687 | |||||
権利 | ||||||
権利情報 | c 2017 Informa UK Limited | |||||
権利 | ||||||
権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Drug Targeting on 02 May 2017, available online: http://www.tandfonline.com/10.1080/1061186X.2017.1315687 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Drug Targeting, 25(8), pp.704-714; 2017 |