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Direct‑acting antiviral treatment decreases serum undercarboxylated osteocalcin in male patients with chronic hepatitis C
http://hdl.handle.net/10069/00041805
http://hdl.handle.net/10069/00041805105cbd6b-502a-41ae-b585-371ef9c7da09
名前 / ファイル | ライセンス | アクション |
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BR17_84 (251.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-10-17 | |||||
タイトル | ||||||
タイトル | Direct‑acting antiviral treatment decreases serum undercarboxylated osteocalcin in male patients with chronic hepatitis C | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatitis C virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | direct‑acting antivirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | undercarboxylated osteocalcin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone metabolic marker | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ichikawa, Tatsuki
× Ichikawa, Tatsuki× Yamashima, Mio× Yamamichi, Shinobu× Koike, Makiko× Nakano, Yusuke× Honda, Tetsurou× Yajima, Hiroyuki× Miyazaki, Osamu× Kuribayashi, Yasutaka× Ikeda, Tomonari× Okamura, Takuma× Nakao, Kazuhiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hepatic osteodystrophy (HOD) is a common complication of chronic liver disease, including viral hepatitis. Hepatitis C virus (HCV) infection is associated with an increased risk of osteoporosis and bone mineral density (BMD) loss. Direct‑acting antiviral (DAA) treatment is used to treat HCV infections; however, its effects on bone metabolism have not been reported. We compared the clinical data and bone metabolic markers at the start of DAA treatment and 1 year later in 78 patients. There were 41 female and 37 male patients. HCV was successfully treated with DAA in all patients. Bone metabolic markers included undercarboxylated osteocalcin (ucOC), 25(OH) vitamin D (VD), total type I procollagen N‑propeptide (P1NP), tartrate‑resistant acid phosphatase 5b (TRACP‑5b), and BMD. BMD was measured in the lumbar spine (mean, L2‑L4) and femoral neck using dual‑energy X‑ray absorptiometry. ucOC in males decreased at 1 year after treatment initiation but not in females. In males, ucOC changes were related to alterations in proteins induced by vitamin K absence‑II (PIVKA‑II), hemoglobin A1c, and TRACP‑5b, which contributed to P1NP and lumbar BMD at the start of DAA. Changes in ucOC among women contributed to the changes in grip strength and TRACP‑5b levels. DAA treatment improved ucOC, a useful bone metabolic marker, in HCV‑infected male patients. Changes in ucOC contributed to changes in PIVKA‑II that likely ameliorated the vitamin K deficiency. DAA treatment has been reported to improve various extrahepatic disorders and abnormal bone metabolism, especially in HOD. | |||||
書誌情報 |
Biomedical Reports 巻 17, 号 5, p. 84, 発行日 2022-09-01 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2049-9434 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/br.2022.1567 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomedical Reports, 17(5), art. no. 84; 2022 |