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Identification of novel orthonairoviruses from rodents and shrews in Gabon, Central Africa
http://hdl.handle.net/10069/00041816
http://hdl.handle.net/10069/00041816ce1914b5-3d48-4844-9cb1-56cbd9d29f10
名前 / ファイル | ライセンス | アクション |
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JGV103_001796.pdf (3.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-10-25 | |||||
タイトル | ||||||
タイトル | Identification of novel orthonairoviruses from rodents and shrews in Gabon, Central Africa | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Orthonairovirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | small mammals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | novel virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gabon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus screening | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | surveillance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ozeki, Takehiro
× Ozeki, Takehiro× Abe, Haruka× Ushijima, Yuri× Nze-Nkogue, Chimène× Akomo-Okoue, Etienne F.× Ella, Ghislain W.E.× Koumba, Lilian B.M.× Nso, Branly C.B.B.× Mintsa-Nguema, Rodrigue× Makouloutou-Nzassi, Patrice× Makanga, Boris K.× Nguelet, Fred L.M.× Ondo, Georgelin N.× Mbadinga, Marien J.V.M.× Igasaki, Yui× Okada, Sayaka× Hirano, Minato× Yoshii, Kentaro× Lell, Bertrand× Bonney, Laura C.× Hewson, Roger× Kurosaki, Yohei× Yasuda, Jiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In Africa, several emerging zoonotic viruses have been transmitted from small mammals such as rodents and shrews to humans. Although no clinical cases of small mammal-borne viral diseases have been reported in Central Africa, potential zoonotic viruses have been identified in rodents in the region. Therefore, we hypothesized that there may be unrecognized zoonotic viruses circulating in small mammals in Central Africa. Here, we investigated viruses that have been maintained among wild small mammals in Gabon to understand their potential risks to humans. We identified novel orthonairoviruses in 24.6 % of captured rodents and shrews from their kidney total RNA samples. Phylogenetic analysis revealed that the novel viruses, Lamusara virus (LMSV) and Lamgora virus, were closely related to Erve virus, which was previously identified in shrews of the genus Crocidura and has been suspected to cause neuropathogenic diseases in humans. Moreover, we show that the LMSV ovarian tumour domain protease, one of the virulence determination factors of orthonairoviruses, suppressed interferon signalling in human cells, suggesting the possible human pathogenicity of this virus. Taken together, our study demonstrates the presence of novel orthonairoviruses that may pose unrecognized risks of viral disease transmission in Gabon. | |||||
書誌情報 |
Journal of General Virology 巻 103, 号 10, p. 001796, 発行日 2022-10-10 |
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出版者 | ||||||
出版者 | Microbiology Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1317 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1099/jgv.0.001796 | |||||
権利 | ||||||
権利情報 | © 2022 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of general virology, 103(10), art. no. 001796; 2022 |