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Novel Antiviral Efficacy of Hedyotis diffusa and Artemisia capillaris Extracts against Dengue Virus, Japanese Encephalitis Virus, and Zika Virus Infection and Immunoregulatory Cytokine Signatures
http://hdl.handle.net/10069/00041857
http://hdl.handle.net/10069/000418570d3581ab-834d-49c3-bfaf-d551ea57d3c3
名前 / ファイル | ライセンス | アクション |
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P11_2589.pdf (3.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-10-31 | |||||
タイトル | ||||||
タイトル | Novel Antiviral Efficacy of Hedyotis diffusa and Artemisia capillaris Extracts against Dengue Virus, Japanese Encephalitis Virus, and Zika Virus Infection and Immunoregulatory Cytokine Signatures | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hedyotis diffusa | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Artemisia capillaris | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inhibition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | flavivirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese encephalitis virus (JEV) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Zika virus (ZIKV) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dengue virus (DENV) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammatory cytokines | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mao, Zhan Qiu
× Mao, Zhan Qiu× Minakawa, Noboru× Moi, Meng Ling |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Currently, there are no specific therapeutics for flavivirus infections, including dengue virus (DENV) and Zika virus (ZIKV). In this study, we evaluated extracts from the plants Hedyotis diffusa (HD) and Artemisia capillaris (AC) to determine the antiviral activity against DENV, ZIKV, and Japanese encephalitis virus (JEV). HD and AC demonstrated inhibitory activity against JEV, ZIKV, and DENV replication and reduced viral RNA levels in a dose–responsive manner, with non-cytotoxic concentration ranging from 0.1 to 10 mg/mL. HD and AC had low cytotoxicity to Vero cells, with CC50 values of 33.7 ± 1.6 and 30.3 ± 1.7 mg/mL (mean ± SD), respectively. The anti-flavivirus activity of HD and AC was also consistent in human cell lines, including human glioblastoma (T98G), human chronic myeloid leukemia (K562), and human embryonic kidney (HEK-293T) cells. Viral-infected, HD-treated cells demonstrated downregulation of cytokines including CCR1, CCL26, CCL15, CCL5, IL21, and IL17C. In contrast, CCR1, CCL26, and AIMP1 were elevated following AC treatment in viral-infected cells. Overall, HD and AC plant extracts demonstrated flavivirus replication inhibitory activity, and together with immunoregulatory cytokine signatures, these results suggest that HD and AC possess bioactive compounds that may further be refined as promising candidates for clinical applications. | |||||
書誌情報 |
Plants 巻 11, 号 19, p. 2589, 発行日 2022-09-30 |
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出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2223-7747 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/plants11192589 | |||||
権利 | ||||||
権利情報 | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Plants, 11(19), art. no. 2589; 2022 |