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Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes
http://hdl.handle.net/10069/00041862
http://hdl.handle.net/10069/00041862420cb81c-3c10-4787-962b-d5b54d6b53f6
名前 / ファイル | ライセンス | アクション |
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MS10_e0112622.pdf (4.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-11-08 | |||||
タイトル | ||||||
タイトル | Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leishmania major | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cutaneous leishmaniasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphocyte-independent pathology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | strain-dependent virulence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neutrophilic inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophage activation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TLR2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Alshaweesh, Jalal
× Alshaweesh, Jalal× Nakamura, Risa× Tanaka, Yuka× Hayashishita, Mizuki× Musa, Abu× Kikuchi, Mihoko× Inaoka, Daniel Ken× Hamano, Shinjiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Infection of C57BL/6 wild-type mice with Leishmania major 5-ASKH or Friedlin strains results in relatively similar pathogenicity with self-healing lesions within weeks. Parasite clearance depends on nitric oxide production by activated macrophages in response to cytokines produced mainly by CD41 Th1 cells. In contrast, C57BL/6 Rag2 knockout mice, which lack T and B lymphocytes, show distinct pathologies during infection with these strains. Despite of the similar parasite number, the 5-ASKH infection induced severe inflammation rather than the Friedlin. To determine the immunological factors behind this phenomenon, we infected C57BL/6 Rag2 knockout mice with these two strains and compared immune cell kinetics and macrophage activation status. Compared with the Friedlin strain, the 5-ASKH strain elicited increased pathology associated with the accumulation of CD11bhigh, Ly6Ghigh neutrophils by week four and increased the expression of macrophage activation markers. We then analyzed the differentially expressed transcripts in infected bone marrow-derived macrophages by RNA sequencing. It showed upregulation of multiple inflammatory transcripts, including Toll-like receptor 1/2 (TLR1/2), CD69, and CARD14, upon 5-ASKH infection. Our findings suggest that different L. major strains can trigger distinct macrophage activation, contributing to the disease outcome observed in the absence of lymphocytes but not in the presence of lymphocytes. | |||||
書誌情報 |
Microbiology Spectrum 巻 10, 号 5, p. e0112622, 発行日 2022-10-03 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2165-0497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/spectrum.01126-22 | |||||
権利 | ||||||
権利情報 | © 2022 Alshaweesh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Microbiology spectrum, 10(5), art. no. e0112622; 2022 |