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Clinical features of non-infectious pulmonary complications after donor lymphocyte infusion in post-transplant patients: The Nagasaki Transplant Group Experience
http://hdl.handle.net/10069/00041868
http://hdl.handle.net/10069/00041868e6dc7805-57c2-4bc8-89b1-b007b5e4a6a3
名前 / ファイル | ライセンス | アクション |
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TI75_101707.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-11-08 | |||||
タイトル | ||||||
タイトル | Clinical features of non-infectious pulmonary complications after donor lymphocyte infusion in post-transplant patients: The Nagasaki Transplant Group Experience | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-infectious pulmonary complications | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Donor lymphocyte infusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graft-versus-host disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hematopoietic stem cell transplantation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fujioka, Machiko
× Fujioka, Machiko× Itonaga, Hidehiro× Furumoto, Takafumi× Sakaki, Chika× Sakamoto, Hikaru× Kato, Takeharu× Horai, Makiko× Taguchi, Masataka× Sawayama, Yasushi× Taguchi, Jun× Imaizumi, Yoshitaka× Yoshida, Shinichiro× Moriuchi, Yukiyoshi× Miyazaki, Yasushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Donor lymphocyte infusion (DLI) is a therapeutic modality for relapsed hematological malignancies after allogeneic hematopoietic stem cell transplantation. We retrospectively analyzed non-infectious pulmonary complications (non-IPCs) following DLI therapy in 41 post-transplant patients with hematological malignancies, and found that 7 developed post-DLI non-IPCs. The 6-year cumulative incidence of non-IPCs was 18.0%. In these patients, non-IPCs were classified into three subtypes: acute respiratory distress syndrome (ARDS), nonspecific interstitial pneumonia (NSIP), and bronchiolitis obliterans syndrome (BOS). The median intervals from the last date of DLI to the development of ARDS and BOS were 12 days (range, 12–14) and 9.4 months (range, 2.6–61.8), respectively; the intervals between DLI and the development of NSIP were 3.5 and 24.7 in 2 patients. Regarding the status of GVHD before the diagnosis with ARDS, 2 out of 3 patients showed the progression of acute GVHD following DLI therapy. One out of 2 patients with NSIP and all 3 patients with BO had chronic GVHD symptoms prior to the development of non-IPCs. In our cohort, 1 patient died of the progression of NSIP. In conclusion, the present study showed the clinical features of non-IPCs following DLI, suggesting the importance of careful followups for non-IPCs in post-DLI patients. | |||||
書誌情報 |
Transplant Immunology 巻 75, p. 101707, 発行日 2022-09-08 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09663274 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.trim.2022.101707 | |||||
権利 | ||||||
権利情報 | ©2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Transplant Immunology, 75, art. no. 101707; 2022 |