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Association between Epstein-Barr virus serological reactivation and psychological distress: a cross-sectional study of Japanese community-dwelling older adults
http://hdl.handle.net/10069/00041923
http://hdl.handle.net/10069/00041923d16cbea6-fd20-460e-a8f0-330b4279914a
名前 / ファイル | ライセンス | アクション |
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A14_8258.pdf (511.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-12-01 | |||||
タイトル | ||||||
タイトル | Association between Epstein-Barr virus serological reactivation and psychological distress: a cross-sectional study of Japanese community-dwelling older adults | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epstein-Barr virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reactivation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | early antigen immunoglobulin G | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | psychological distress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | depression | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamanashi, Hirotomo
× Yamanashi, Hirotomo× Akabame, Shogo× Miyata, Jun× Honda, Yukiko× Nonaka, Fumiaki× Shimizu, Yuji× Nakamichi, Seiko× Kawashiri, Shin-Ya× Tamai, Mami× Arima, Kazuhiko× Kawakami, Atsushi× Aoyagi, Kiyoshi× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Reactivation of Epstein-Barr virus (EBV) is associated with the etiopathogenesis of a broad spectrum of diseases. This study aimed to investigate the association between psychological distress and EBV serological reactivation among community-dwelling older people and assess the role of sex differences in this association. This population-based cross-sectional survey was conducted among individuals who underwent annual health checkups (N = 2,821; median age 72.4 years). EBV serological reactivation was defined as elevation of EBV early antigen immunoglobulin G titers, and psychological distress was defined as Kessler 6 scores ≥5. Multivariable logistic regression analysis was performed to calculate odds ratios (OR) and 95% confidence intervals (CI) for EBV serological reactivation and psychological distress. EBV serological reactivation and psychological distress were detected in 16.4% and 8.7% of participants, respectively. Women accounted for 71% (328/463) of those with EBV serological reactivation. Multivariable logistic regression analysis showed psychological distress was not significantly associated with EBV serological reactivation among all participants (OR 1.31, 95% CI: 0.95, 1.82; P = 0.102). A sex-stratified multivariable analysis showed a positive association among women (OR 1.45, 95% CI: 1.01, 2.08; P = 0.043), but no association among men. EBV serological reactivation was independently associated with psychological distress in community-dwelling older women. The sex difference in our results warrants further investigation to clarify the physiological mechanisms underlying the association. | |||||
書誌情報 |
Aging 巻 14, 号 20, p. 8258-8269, 発行日 2022-10-21 |
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出版者 | ||||||
出版者 | Impact Journals LLC | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1945-4589 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/aging.204345 | |||||
権利 | ||||||
権利情報 | © 2022 Yamanashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Aging, 14(20), pp.8258-8269; 2022 |