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Compound K: A systematic review of its anticancer properties and probable mechanisms
http://hdl.handle.net/10069/00042026
http://hdl.handle.net/10069/000420261594f5d3-a34b-4218-8d63-89d00e7d2151
名前 / ファイル | ライセンス | アクション |
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FCP_1.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-02-02 | |||||
タイトル | ||||||
タイトル | Compound K: A systematic review of its anticancer properties and probable mechanisms | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anticancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | compound K | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ginsenosides | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in vitro | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in vivo | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | systematic review | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tam, Dao Ngoc Hien
× Tam, Dao Ngoc Hien× Nam, Nguyen Hai× Cuong, Nguyen The Ky× Hung, Dang The× Soa, Dang Thi× Altom, Ahmad× Tran, Linh× Elhadad, Heba× Huy, Nguyen Tien |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Panax ginseng is a common natural product, which is well-known to have a wide range of pharmacological activities in cancer. Its metabolite, compound K (CK), has been reported to have anticancer activity. We aimed to systematically review the literature for evidence of anticancer effects of CK. We conducted a systematic search in eight databases. We included all in vitro and in vivo studies investigating the anticancer effects of CK with no restrictions. Quality assessment was applied by ToxRTool. Fifty-four articles were included in our study. The purity of CK in our included studies was at least 95%. The in vitro studies reported that CK had a potential anticancer activity on several cell lines including human lung cancer cell lines (A549, PC-9), nasopharyngeal carcinoma cell line (Hk-1), liver cancer cell line (BEL 7402), and pediatric acute myeloid leukemia cell lines (Kasumi-1, MV4-11). The in vivo studies reported a significant decrease in tumor volume in mice treated with CK. CK is a potential supplementary treatment in cancer chemotherapies. The safety and further clinical trials of CK should be explored for future drug development. | |||||
書誌情報 |
Fundamental & Clinical Pharmacology p. 1-29, 発行日 2023-01-31 |
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出版者 | ||||||
出版者 | John Wiley & Sons, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0767-3981 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/fcp.12874 | |||||
権利 | ||||||
権利情報 | © 2023 Société Française de Pharmacologie et de Thérapeutique. This is the peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/10.1111/fcp.12874, which has been published in final form at https://doi.org/10.1111/fcp.12874. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Fundamental & Clinical Pharmacology, pp.1-29; 2023. doi:10.1111/fcp.12874 |