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Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients
http://hdl.handle.net/10069/00042333
http://hdl.handle.net/10069/00042333f16a5445-adc3-4498-bd51-9acc899ed5a1
名前 / ファイル | ライセンス | アクション |
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ISYK1499_Nagaoka.pdf (1.3 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2023-04-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myasthenia gravis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Motor end-plate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Complement | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clustered AChR antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Seronegative | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
長岡, 篤志
× 長岡, 篤志 |
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著者別名 | ||||||
姓名 | Nagaoka, Atsushi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study aimed to evaluate the diagnostic usefulness of motor end-plate (MEP) analysis along with clustered acetylcholine receptor (AChR) antibody (Ab) assays in patients with myasthenia-like symptoms but negative routine AChR and muscle-specific kinase (MuSK) Ab tests. MEP analysis of muscle biopsies of the biceps brachii was performed in 20 patients to try to differentiate between those with or without immune-mediated myasthenia gravis (MG). Using a quantitative method, complement C3 deposition and AChR densities in MEPs were examined. Independently, cell-based assays were used to detect serum clustered-AChR Abs. Only five of 20 patients had complement deposition at MEPs; four of these patients had reduced AChR densities similar to those in patients with typical AChR Ab positive MG, and distinct from those in the remaining 15 patients. Two of the four serum samples from these patients had clustered-AChR Abs. All complement-positive patients were considered as having immune-mediated MG and improved with appropriate treatments; although one patient presented with MG 3 years later, the remaining patients had other diagnoses during over 10 years of follow-up. These results suggest the usefulness of MEP analysis of muscle biopsies in diagnosing immune-mediated MG in seronegative patients with myasthenia-like symptoms but, due to the invasiveness of the muscle biopsy procedure, clustered AChR Abs should, if possible, be tested first. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1499号 学位授与年月日:令和5年3月1日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Atsushi Nagaoka, Akira Tsujino, Hirokazu Shiraishi, Tadashi Kanamoto, Tomoaki Shima, Shunsuke Yoshimura, Teiichiro Miyazaki, Yohei Tateishi, Mitsuhiro Tsujihata, Masakatsu Motomura, Susan Maxwell, Osamu Higuchi, David Beeson, Angela Vincent | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Journal of the Neurological Sciences, 443, art. no. 120494; 2022 | |||||
書誌情報 |
Journal of the Neurological Sciences 巻 443, p. 120494, 発行日 2023-03-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022510X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jns.2022.120494 | |||||
権利 | ||||||
権利情報 | © 2022 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 血清反応陰性患者における免疫介在性重症筋無力症診断のための運動終板の解析 | |||||
出版者 | ||||||
出版者 | Elsevier B.V. | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/00042232 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2023-03-01 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1499号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2023-03-01) |