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However, some of these patients have poor prognoses despite such intensive treatment. Other more effective treatments are desired. We report the case of an anti-MDA5 Ab-positive DM patient who had developed RPILD despite intensive treatments; she was treated successfully by a short-term plasma exchange (PE). Patient concerns: A 71-year-old Japanese woman was admitted to the rheumatology department of another hospital with progressive muscle weakness of the limbs and erythema on both upper eyelids and the fingers of both hands. She was suspected of having classical DM (CDM) based on the findings of typical skin and myositis. Although a chest computed tomography (CT) examination showed no findings of interstitial pneumonia at the first visit to the department, she newly presented interstitial pneumonia during her admission and her anti-MDA5 Ab titer was elevated. Diagnoses: She was diagnosed with interstitial lung disease (ILD) with anti-MDA5 Ab-positive DM. Interventions: She was treated with 1000mg of methyl-prednisolone pulse, 500mg of intravenous cyclophosphamide therapy (IVCY) followed by prednisolone 40mg/day with tapering, and oral cyclosporine 200mg/day. However, her interstitial pneumonia worsened with increasing breathing difficulty and an increasing serum ferritin level. She was transferred to our department, and we initiated PE as an additional treatment. Outcomes: After the PE treatment, all laboratory findings, for example, ferritin, KL-6, and the titer of anti-MDA5 Ab showed marked improvement, and the patient\u0027s skin symptoms and active interstitial pneumonia were relieved. 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Successful treatment of plasma exchange for rapidly progressive interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis
http://hdl.handle.net/10069/38225
http://hdl.handle.net/10069/382253319880e-d29d-464a-9083-94f441358db4
名前 / ファイル | ライセンス | アクション |
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Medicine97_436.pdf (490.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-05-29 | |||||
タイトル | ||||||
タイトル | Successful treatment of plasma exchange for rapidly progressive interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-MDA5 antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clinically amyopathic dermatomyositis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dermatomyositis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interstitial pneumonia, Plasma exchange | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Endo, Yushiro
× Endo, Yushiro× Koga, Tomohiro× Suzuki, Takahisa× Hara, Kazusato× Ishida, Midori× Fujita, Yuya× Tsuji, Sosuke× Takatani, Ayuko× Shimizu, Toshimasa× Sumiyoshi, Remi× Igawa, Takashi× Umeda, Masataka× Fukui, Shoichi× Nishino, Ayako× Kawashiri, Shin-ya× Iwamoto, Naoki× Ichinose, Kunihiro× Tamai, Mami× Nakamura, Hideki× Origuchi, Tomoki× Kuwana, Masataka× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Rationale: As the initial treatment of rapidly progressive interstitial lung disease (RPILD) with antimelanoma differentiationassociated gene 5 antibody (anti-MDA5 Ab)-positive dermatomyositis (DM) patients, a combination of corticosteroids, cyclophosphamide, and calcineurin inhibitor is recommended. However, some of these patients have poor prognoses despite such intensive treatment. Other more effective treatments are desired. We report the case of an anti-MDA5 Ab-positive DM patient who had developed RPILD despite intensive treatments; she was treated successfully by a short-term plasma exchange (PE). Patient concerns: A 71-year-old Japanese woman was admitted to the rheumatology department of another hospital with progressive muscle weakness of the limbs and erythema on both upper eyelids and the fingers of both hands. She was suspected of having classical DM (CDM) based on the findings of typical skin and myositis. Although a chest computed tomography (CT) examination showed no findings of interstitial pneumonia at the first visit to the department, she newly presented interstitial pneumonia during her admission and her anti-MDA5 Ab titer was elevated. Diagnoses: She was diagnosed with interstitial lung disease (ILD) with anti-MDA5 Ab-positive DM. Interventions: She was treated with 1000mg of methyl-prednisolone pulse, 500mg of intravenous cyclophosphamide therapy (IVCY) followed by prednisolone 40mg/day with tapering, and oral cyclosporine 200mg/day. However, her interstitial pneumonia worsened with increasing breathing difficulty and an increasing serum ferritin level. She was transferred to our department, and we initiated PE as an additional treatment. Outcomes: After the PE treatment, all laboratory findings, for example, ferritin, KL-6, and the titer of anti-MDA5 Ab showed marked improvement, and the patient's skin symptoms and active interstitial pneumonia were relieved. Lessons: Our patient's case suggests that PE may be effective for RPILD in anti-MDA5 Ab-positive DM patients. | |||||
書誌情報 |
Medicine 巻 97, 号 15, p. e0436, 発行日 2018-04-01 |
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出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00257974 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/MD.0000000000010436 | |||||
権利 | ||||||
権利情報 | c 2018 the Author(s). Published by Wolters Kluwer Health, Inc. | |||||
権利 | ||||||
権利情報 | This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medicine, 97(15), e0436; 2018 |