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Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species
http://hdl.handle.net/10069/38263
http://hdl.handle.net/10069/38263db99fbbe-bcad-4635-86d5-e9b6eef95021
名前 / ファイル | ライセンス | アクション |
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JGV99_181.pdf (2.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-06 | |||||
タイトル | ||||||
タイトル | Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ebola virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glycoprotein viral infectivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Niemann-pick C1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reston virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Virus-host interaction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kurosaki, Yohei
× Kurosaki, Yohei× Ueda, Mahoko Takahashi× Nakano, Yusuke× Yasuda, Jiro× Koyanagi, Yoshio× Sato, Kei× Nakagawa, So |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ebola virus (EBOV), which belongs to the genus Ebolavirus, causes a severe and often fatal infection in primates, including humans, whereas Reston virus (RESTV) only causes lethal disease in non-human primates. Two amino acids (aa) at positions 82 and 544 of the EBOV glycoprotein (GP) are involved in determining viral infectivity. However, it remains unclear how these two aa residues affect the infectivity of Ebolavirus species in various hosts. Here we performed viral pseudotyping experiments with EBOV and RESTV GP derivatives in 10 cell lines from 9 mammalian species. We demonstrated that isoleucine at position 544/545 increases viral infectivity in all host species, whereas valine at position 82/83 modulates viral infectivity, depending on the viral and host species. Structural modelling suggested that the former residue affects viral fusion, whereas the latter residue influences the interaction with the viral entry receptor, Niemann-Pick C1. | |||||
書誌情報 |
Journal of General Virology en : Journal of General Virology 巻 99, 号 2, p. 181-186, 発行日 2018-02 |
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出版者 | ||||||
出版者 | Society for General Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00221317 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14652099 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1099/jgv.0.000999 | |||||
権利 | ||||||
権利情報 | c 2018 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of General Virology, 99(2), pp.181-186; 2018 |