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Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men
http://hdl.handle.net/10069/38269
http://hdl.handle.net/10069/38269ad9b2edd-97f2-4224-a5a7-c1f678ac048f
名前 / ファイル | ライセンス | アクション |
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Onco9_7749.pdf (3.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-06 | |||||
タイトル | ||||||
タイトル | Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD34-positive cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CIMT, Height | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Platelets | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vascular remodeling | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Sato, Shimpei× Koyamatsu, Jun× Yamanashi, Hirotomo× Nagayoshi, Mako× Kadota, Koichiro× Kawashiri, Shin-Ya× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (? 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = ?0.22, p = 0.019 for subjects with high hemoglobin, and β = ?0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature. | |||||
書誌情報 |
Oncotarget 巻 9, 号 8, p. 7749-7757, 発行日 2018-01-30 |
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出版者 | ||||||
出版者 | Impact Journals LLC | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19492553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.23660 | |||||
権利 | ||||||
権利情報 | c Shimizu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncotarget, 9(8), pp.7749-7757; 2018 |