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Uptake of Aortic 18F-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population
http://hdl.handle.net/10069/36268
http://hdl.handle.net/10069/3626875550c15-51d5-4588-94b7-b11cf07dba8a
名前 / ファイル | ライセンス | アクション |
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ISYK831_Haraguchi.pdf (1.3 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-03-30 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Uptake of Aortic 18F-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
原口, 愛
× 原口, 愛 |
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著者別名 | ||||||
姓名 | Haraguchi, Ai | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: This study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population. Methods: 18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings. Results: By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (b = 0.001, p = 0.03) and log-leptin (b = 0.336, p,0.01) in all subjects. Conclusion: TBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic 18F-FDG uptake is a good marker of atherosclerosis, even in a general population. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第831号 学位授与年月日:平成28年3月18日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Ai Haraguchi, Naomi Hayashida, Toshihiko Kamasaki, Izumi Miyamoto, Toshiya Usui, Takao Ando, Norio Abiru, Hironori Yamasaki, Kenya Chiba, Takashi Kudo, Atsushi Kawakami, Noboru Takamura | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: PLoS ONE, 9(11), e111990; 2014 | |||||
書誌情報 |
PLoS ONE 巻 9, 号 11, p. e111990, 発行日 2016-03-18 |
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EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0111990 | |||||
権利 | ||||||
権利情報 | (C) 2014 Haraguchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 一般住民における大動脈のFDG集積はLDLコレステロール及びレプチンと関連する | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/36499 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-18 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第831号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2016-03-18) |