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Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi
http://hdl.handle.net/10069/39520
http://hdl.handle.net/10069/39520120d3d91-a38e-42a3-875c-c5a401a7486a
名前 / ファイル | ライセンス | アクション |
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ParaInt74_101994.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-12 | |||||
タイトル | ||||||
タイトル | Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD4+ T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-27 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-10 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protective immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunological memory | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sukhbaatar, Odsuren
× Sukhbaatar, Odsuren× Kimura, Daisuke× Miyakoda, Mana× Nakamae, Sayuri× Kimura, Kazumi× Hara, Hiromitsu× Yoshida, Hiroki× Inoue, Shin-Ichi× Yui, Katsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | IL-27, a regulatory cytokine, plays critical roles in the prevention of immunopathology during Plasmodium infection. We examined these roles in the immune responses against Plasmodium chabaudi infection using the Il-27ra?/? mice. While IL-27 was expressed at high levels during the early phase of the infection, enhanced CD4+ T cell function and reduction in parasitemia were observed mainly during the chronic phase in the mutant mice. In mice infected with P. chabaudi and cured with drug, CD4+ T cells in the Il-27ra?/? mice exhibited enhanced CD4+ T-cell responses, indicating the inhibitory role of IL-27 on the protective immune responses. To determine the role of IL-27 in detail, we performed CD4+ T-cell transfer experiments. The Il-27ra?/? and Il27p28?/? mice were first infected with P. chabaudi and then cured using drug treatment. Plasmodium-antigen primed CD4+ T cells were prepared from these mice and transferred into the recipient mice, followed by infection with the heterologous parasite P. berghei ANKA. Il-27ra?/? CD4+ T cells in the infected recipient mice did not produce IL-10, indicating that IL-10 production by primed CD4+ T cells is IL-27 dependent. Il27p28?/? CD4+ T cells that were primed in the absence of IL-27 exhibited enhanced recall responses during the challenge infection with P. berghei ANKA, implying that IL-27 receptor signaling during the primary infection affects recall responses in the long-term via the regulation of the memory CD4+ T cell generation. These features highlighted direct and time-transcending roles of IL-27 in the regulation of immune responses against chronic infection with Plasmodium parasites. | |||||
書誌情報 |
Parasitology International 巻 74, p. 101994, 発行日 2019-10-19 |
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出版者 | ||||||
出版者 | Elsevier Ireland Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13835769 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.parint.2019.101994 | |||||
権利 | ||||||
権利情報 | c 2019 The Author(s) Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/BY-NC-ND/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Parasitology International, 74, art.no.101994; 2019 |