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Less Invasive Corneal Transepithelial Electrical Resistance Measurement Method
http://hdl.handle.net/10069/36935
http://hdl.handle.net/10069/369351a2346c7-68e9-41d3-b0dc-9a2d46cd8142
名前 / ファイル | ライセンス | アクション |
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OculSurf14_37.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-02-01 | |||||
タイトル | ||||||
タイトル | Less Invasive Corneal Transepithelial Electrical Resistance Measurement Method | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | benzalkonium chloride | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cornea | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transepithelial electrical resistance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Uematsu, Masafumi
× Uematsu, Masafumi× Mohamed, Yasser Helmy× Onizuka, Naoko× Ueki, Ryotaro× Inoue, Daisuke× Fujikawa, Azusa× Sasaki, Hitoshi× Kitaoka, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To evaluate acute corneal permeability changes after instillation of benzalkonium chloride (BAC) using a newly developed in vivo less invasive corneal transepithelial electrical resistance (TER) measurement method in animals and humans. Methods: We previously developed an in vivo method for measuring corneal TER using intraocular electrodes in animals. This method can be used to precisely measure the decline of the corneal barrier function after instillation of BAC. To lessen the invasiveness of that procedure, we further refined the method for measuring the corneal TER by developing electrodes that could be placed on the surface of the cornea and in the conjunctival sac instead of inserting them into the anterior chamber. Corneal TER changes before and after exposure to 0.02% BAC were determined in this study using the new device in both rabbits and humans. Results: There was a significant decrease in the corneal TER after exposure of the cornea to 0.02% BAC solution in both rabbits and humans (P<.01). The results of this new less invasive method agreed with those of formerly established anterior chamber methods in rabbit experiments. Conclusion: This new less invasive corneal TER measurement method enables us for the first time to measure TER of the human cornea, allowing safe and reliable investigation of the direct effect of different eye drop treatments on the corneal epithelium. | |||||
書誌情報 |
The Ocular Surface 巻 14, 号 1, p. 37-42, 発行日 2016-01 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15420124 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jtos.2015.07.004 | |||||
権利 | ||||||
権利情報 | c 2016 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Ocular Surface, 14(1), pp.37-42; 2016 |