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Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice
http://hdl.handle.net/10069/39560
http://hdl.handle.net/10069/39560ca1a6e87-750e-4792-8416-d77f82935a10
名前 / ファイル | ライセンス | アクション |
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Bone112_177.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-27 | |||||
タイトル | ||||||
タイトル | Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bisphosphonates | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cyclophosphamide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bisphosphonate-related osteonecrosis of the jaw | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wound healing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dose effect | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kuroshima, Shinichiro
× Kuroshima, Shinichiro× Sasaki, Muneteru× Nakajima, Kazunori× Tamaki, Saki× Hayano, Hiroki× Sawase, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bisphosphonate-related osteonecrosis of the jaw (BRONJ) worsens oral health-related quality of life. Most BRONJ occurs in multiple myeloma or metastatic breast cancer patients treated with bisphosphonate/chemotherapeutic combination therapies. Cyclophosphamide (CY), an alkylating chemotherapeutic drug, is used to treat multiple myeloma, although its use has been recently reduced. The aim of this study was to clarify the effects of CY dose on tooth extraction socket healing when CY is used with or without bisphosphonate in mice. Low-dose CY (50?mg/kg; CY-L), moderate-dose CY (100?mg/kg; CY-M), high-dose CY (150?mg/kg; CY-H), and bisphosphonate [Zometa (ZA): 0.05?mg/kg] were administered for 7?weeks. Each dose of CY and ZA in combination was also administered for 7?weeks. Both maxillary first molars were extracted at 3?weeks after the initiation of drug administration. Euthanasia was performed at 4?weeks post-extraction. Gross wound healing, microcomputed tomography analysis, histomorphometry, and immunohistochemistry were used to quantitatively evaluate osseous and soft tissue wound healing of tooth extraction sockets. ZA monotherapy induced no BRONJ-like lesions in mice. CY monotherapy rarely induced open wounds, though delayed osseous wound healing occurred in a CY dose-dependent manner. In contrast, CY/ZA combination therapy prevalently induced BRONJ-like lesions with compromised osseous and soft tissue healing in a CY dose-dependent manner. Interestingly, anti-angiogenesis was noted regardless of CY dose and ZA administration, even though only CY-M/ZA and CY-H/ZA combination therapies induced BRONJ-like lesions. Our findings suggest that high-dose CY may be associated with the development of BRONJ following tooth extraction only when CY is used together with ZA. In addition to anti-angiogenesis, other factors may contribute to the pathoetiology of BRONJ. | |||||
書誌情報 |
Bone 巻 112, p. 177-186, 発行日 2018-05-02 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 87563282 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bone.2018.05.001 | |||||
権利 | ||||||
権利情報 | c 2018 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone, 112, pp.177-186; 2018 |