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An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines
http://hdl.handle.net/10069/39569
http://hdl.handle.net/10069/39569b35bfcbe-ce4d-4a33-99ba-9d40563dda18
名前 / ファイル | ライセンス | アクション |
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JJID72_413.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-12-05 | |||||
タイトル | ||||||
タイトル | An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dengue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | emergence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Philippines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genotype | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Luz, Mark Anthony de Vera
× Luz, Mark Anthony de Vera× Nabeshima, Takeshi× Moi, Meng Ling× Dimamay, Maria Terrese Alonzo× Pangilinan, Lady-Anne Suarez× Dimamay, Mark Pierre Sijo× Matias, Ronald Roll× Mapua, Cynthia Abad× Buerano, Corazon Cerilla× de, Guzman Ferdinand× Tria, Edith Sangalang× Natividad, Filipinas Florendo× Daroy, Maria Luisa de Guzman× Takemura, Taichiro× Hasebe, Futoshi× Morita, Kouichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | engue remains a major public health problem in the Philippines. In this study, we determined the circulating dengue serotypes in the Philippines during the 2015?2017 outbreaks using a total of 678 serum samples from 537 individual dengue patients. Following an increase in the number of DENV-4 patients in recent years, we conducted a comprehensive molecular and epidemiology analysis on the DENV-4 strains isolated recently in the Philippines. Two genotypes of DENV-4 have been isolated in the Philippines since 1956: GI and GIIa. The GIIa DENV strains that were isolated in the present study were closely related to a distinct group of GIIa strains that were isolated from the Philippines in 2004. A majority of the isolates of this sub-group have been identified in the Philippines, suggesting that this lineage may have been introduced in the Philippines, and evolved to form the distinct sub-group within GIIa strains. The increase in DENV-4 activity also coincided with the appearance of the GIIa sub-group and the phasing-out of the GI lineage in the Philippines. Overall, our study demonstrates a shift in DENV-4 genotype and epidemic dynamics in a hyperendemic region, suggesting the importance of DENV genetic evolution in establishing and sustaining transmission. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 72, 号 6, p. 413-419, 発行日 2019-11-21 |
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出版者 | ||||||
出版者 | 国立感染症研究所 | |||||
出版者別言語 | ||||||
National Institute of Health | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18842836 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.JJID.2019.208 | |||||
権利 | ||||||
権利情報 | c 2019, National Institute of Health. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 72(6), pp.413-419; 2019 |