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Involvement of calpains in adult neurogenesis: implications for stroke
http://hdl.handle.net/10069/35167
http://hdl.handle.net/10069/35167fe28126b-9d8e-4084-bebd-116fbf637da8
名前 / ファイル | ライセンス | アクション |
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Fncel9_22.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-31 | |||||
タイトル | ||||||
タイトル | Involvement of calpains in adult neurogenesis: implications for stroke | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calpains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calpastatin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hippocampus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Migration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neurogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proliferation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stroke | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Subventricular zone | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Machado, Vanessa M.
× Machado, Vanessa M.× Morte, Maria Ines× Carreira, Bruno Pereira× Azevedo, Maria M.× Takano, Jiro× Iwata, Nobuhisa× Saido, Takaomi Comings× Asmussen, Hannelore× Horwitz, Alan Rick× Carvalho, Caetana Monteiro× Araujo, Ines Maria |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Calpains are ubiquitous proteases involved in cell proliferation, adhesion and motility. In the brain, calpains have been associated with neuronal damage in both acute and neurodegenerative disorders, but their physiological function in the nervous system remains elusive. During brain ischemia, there is a large increase in the levels of intracellular calcium, leading to the activation of calpains. Inhibition of these proteases has been shown to reduce neuronal death in a variety of stroke models. On the other hand, after stroke, neural stem cells (NSC) increase their proliferation and newly formed neuroblasts migrate towards the site of injury. However, the process of forming new neurons after injury is not efficient and finding ways to improve it may help with recovery after lesion. Understanding the role of calpains in the process of neurogenesis may therefore open a new window for the treatment of stroke. We investigated the involvement of calpains in NSC proliferation and neuroblast migration in two highly neurogenic regions in the mouse brain, the dentate gyrus (DG) and the subventricular zone (SVZ). We used mice that lack calpastatin, the endogenous calpain inhibitor, and calpains were also modulated directly, using calpeptin, a pharmacological calpain inhibitor. Calpastatin deletion impaired both NSC proliferation and neuroblast migration. Calpain inhibition increased NSC proliferation, migration speed and migration distance in cells from the SVZ. Overall, our work suggests that calpains are important for neurogenesis and encourages further research on their neurogenic role. Prospective therapies targeting calpain activity may improve the formation of new neurons following stroke, in addition to affording neuroprotection. | |||||
書誌情報 |
Frontiers in Cellular Neuroscience 巻 9, p. 22, 発行日 2015-02-04 |
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出版者 | ||||||
出版者 | Frontiers Research Foundation | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16625102 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fncel.2015.00022 | |||||
権利 | ||||||
権利情報 | c 2015 Machado, Morte, Carreira, Azevedo, Takano, Iwata, Saido, Asmussen, Horwitz, Carvalho and Araujo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Frontiers in Cellular Neuroscience, 9, 22; 2015 |