WEKO3
アイテム
{"_buckets": {"deposit": "f37c0aa2-268e-4dbb-ad54-f7e74673a21c"}, "_deposit": {"created_by": 6, "id": "4088", "owners": [6], "pid": {"revision_id": 0, "type": "depid", "value": "4088"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00004088", "sets": ["24"]}, "author_link": ["114625", "114624"], "item_5_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "日本人MuSK抗体陽性重症筋無力症患者の胸腺組織と自己免疫疾患の合併"}]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-06-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "1276", "bibliographicPageStart": "1272", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "European Journal of Neurology"}]}]}, "item_5_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2013-06-05"}]}, "item_5_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "Nagasaki University (長崎大学)"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17301", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto\u0027s thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves\u0027 disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG.", "subitem_description_type": "Abstract"}]}, "item_5_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "長崎大学学位論文 学位記番号:博(医歯薬)甲第604号 学位授与年月日:平成25年6月5日", "subitem_description_type": "Other"}, {"subitem_description": "Author: Nakata Ruka , Motomura Masakatsu , Masuda Tomoko , Shiraishi Hirokazu , Tokuda Masahiro , Fukuda Taku , Ando Takao ,Yoshimura Toshiro , Tsujihata Mitsuhiro , Kawakami Atsushi", "subitem_description_type": "Other"}, {"subitem_description": "Citation: European Journal of Neurology, 20(9), pp.1272-1276; 2013", "subitem_description_type": "Other"}]}, "item_5_description_69": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Nagasaki University (長崎大学), 博士(医学) (2013-06-05)", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲医歯薬第604号"}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "114625", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakata, Ruka"}]}]}, "item_5_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Blackwell Publishing"}]}, "item_5_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/ene.12169", "subitem_relation_type_select": "DOI"}}]}, "item_5_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://hdl.handle.net/10069/34114", "subitem_relation_type_select": "HDL"}}]}, "item_5_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2013 EFNS."}, {"subitem_rights": "This is the accepted version of the following article: European Journal of Neurology, 20(9), pp.1272-1276; 2013, which has been published in final form at http://dx.doi.org/10.1111/ene.12169"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13515101", "subitem_source_identifier_type": "ISSN"}]}, "item_5_text_67": {"attribute_name": "学位の種類", "attribute_value_mlt": [{"subitem_text_value": "課程博士"}]}, "item_5_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "中田, るか"}], "nameIdentifiers": [{"nameIdentifier": "114624", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-02-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ISYK604_Nakata.pdf", "filesize": [{"value": "173.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 173700.0, "url": {"label": "ISYK604_Nakata.pdf", "objectType": "fulltext", "url": "https://nagasaki-u.repo.nii.ac.jp/record/4088/files/ISYK604_Nakata.pdf"}, "version_id": "f2f1547d-2c92-4872-a8c8-eefb47369a9a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Associated autoimmune disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Muscle-specific receptor tyrosine kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Myasthenia gravis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Thymus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Titin antibodies", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "6", "path": ["24"], "permalink_uri": "http://hdl.handle.net/10069/35201", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2015-04-08"}, "publish_date": "2015-04-08", "publish_status": "0", "recid": "4088", "relation": {}, "relation_version_is_last": true, "title": ["Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis"], "weko_shared_id": -1}
Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis
http://hdl.handle.net/10069/35201
http://hdl.handle.net/10069/35201c48a7f90-02aa-4333-8cf1-a383fadefe16
名前 / ファイル | ライセンス | アクション |
---|---|---|
ISYK604_Nakata.pdf (173.7 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-04-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Associated autoimmune disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Muscle-specific receptor tyrosine kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myasthenia gravis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thymus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Titin antibodies | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
中田, るか
× 中田, るか |
|||||
著者別名 | ||||||
姓名 | Nakata, Ruka | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第604号 学位授与年月日:平成25年6月5日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Nakata Ruka , Motomura Masakatsu , Masuda Tomoko , Shiraishi Hirokazu , Tokuda Masahiro , Fukuda Taku , Ando Takao ,Yoshimura Toshiro , Tsujihata Mitsuhiro , Kawakami Atsushi | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: European Journal of Neurology, 20(9), pp.1272-1276; 2013 | |||||
書誌情報 |
European Journal of Neurology 巻 20, 号 9, p. 1272-1276, 発行日 2013-06-05 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13515101 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/ene.12169 | |||||
権利 | ||||||
権利情報 | c 2013 EFNS. | |||||
権利 | ||||||
権利情報 | This is the accepted version of the following article: European Journal of Neurology, 20(9), pp.1272-1276; 2013, which has been published in final form at http://dx.doi.org/10.1111/ene.12169 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 日本人MuSK抗体陽性重症筋無力症患者の胸腺組織と自己免疫疾患の合併 | |||||
出版者 | ||||||
出版者 | Blackwell Publishing | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/34114 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2013-06-05 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第604号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2013-06-05) |