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Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-α-Induced Permeability In Vitro
http://hdl.handle.net/10069/35248
http://hdl.handle.net/10069/35248753fc9e8-0dbb-451c-a454-23540bf8efef
名前 / ファイル | ライセンス | アクション |
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ISYK635_Raekiansyah.pdf (323.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2015-04-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-α-Induced Permeability In Vitro | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Raekiansyah, Muhareva
× Raekiansyah, Muhareva |
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著者別名 | ||||||
姓名 | ライキエンシャ, ムハレバ | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The mechanisms of endothelial barrier dysfunction in dengue disease remain poorly understood. Endothelial cell (EC) death due to virus infection or in combination with an infection-induced cytokine storm is deemed as one of the major causes of plasma leakage. Using an in vitro model of human endothelia and several dengue virus (DENV) strains (including a clinical isolate), the direct consequence of infection on endothelial permeability was investigated throughout the course of the infection. All employed DENV-2 strains were able to infect and replicate in ECs. Rather than increase endothelial permeability, DENV infection alone enhanced cell barrier integrity up to 7 days postinfection. Improved cell barrier function was mediated by type I interferon activation at the early phase of infection and by the survival advantage of the infected cells at the late phase of infection. Consistent with this phenomenon, DENV infection did not augment tumor necrosis factor-α-induced permeability. Our results prove that DENV infection does not directly account for vascular permeability; DENV neither induces hyperpermeability nor exacerbates the permeabilizing effect of cytokines. The contributory role of other factors on plasma leakage during dengue disease warrants further investigation. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第635号 学位授与年月日:平成25年10月2日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Muhareva Raekiansyah, Lyre Anni Espada-Murao, Kenta Okamoto, Toru Kubo, Kouichi Morita | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Japanese Journal of Infectious Diseases, 67(2), pp.86-94; 2014 | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 67, 号 2, p. 86-94, 発行日 2013-10-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.67.86 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | デングウイルスの感染はそれのみで血管の透過性を亢進する作用はなくTNF-αの透過性亢進作用を増強することもない | |||||
出版者 | ||||||
出版者 | 国立感染症研究所 | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/34146 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2013-10-02 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第635号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2013-10-02) |