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Distinguishing MDS from other cytopenias is sometimes difficult even for trained hematologists. WT1, the gene mutated in Wilms’ tumor, was found expressed in acute myeloid leukemia and MDS. The amount of WT1 in peripheral blood and bone marrow (BM) is low in low-risk MDS subtypes, and is high in high-risk MDS subtypes. However, the role of WT1 in the differential diagnosis between MDS and other diseases showing cytopenia has not been fully addressed. The present study evaluated whether WT1 expression level can assist in the differential diagnosis of MDS from other cytopenias. Methods The amount of WT1 message was evaluated among 56 MDS patients and 47 patients with cytopenia for various other reasons (cytopenia VR) at the Nagasaki University Hospital. Results The level of WT1 was significantly related to the percentage of blasts in BM among MDS cases, and the type of French-American-British classification of MDS; refractory anemia (RA) cases showed significantly lower WT1 level than patients with RA with excess blasts. WT1 level was significantly related to the prognostic risk categories of MDS by the International Prognostic Scoring System (IPSS) and the revised IPSS. Although the blast percentage in the BM of RA and cytopenia VR were both less than 5%, there was a significant difference in the level of WT1 between MDS and cytopenia VR. 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The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons
http://hdl.handle.net/10069/35257
http://hdl.handle.net/10069/3525777452f29-f079-49b7-b272-5a1d6f50fa31
名前 / ファイル | ライセンス | アクション |
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IntMed54_445.pdf (337.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-04-30 | |||||
タイトル | ||||||
タイトル | The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytopenia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IPSS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IPSS-R | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myelodysplastic syndromes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | WT1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Baba, Maki
× Baba, Maki× Hata, Tomoko× Tsushima, Hideki× Mori, Sayaka× Sasaki, Daisuke× Turuta, Kazuto× Hasegawa, Hiroo× Ando, Koji× Sawayama, Yasushi× Imanishi, Daisuke× Taguchi, Jun× Yanagihara, Katsunori× Tomonaga, Masao× Kamihira, Shimeru× Miyazaki, Yasushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective Myelodysplastic syndromes (MDS) are a group of hematological neoplasms associated with ineffective hematopoiesis and that transform to acute leukemia. Distinguishing MDS from other cytopenias is sometimes difficult even for trained hematologists. WT1, the gene mutated in Wilms’ tumor, was found expressed in acute myeloid leukemia and MDS. The amount of WT1 in peripheral blood and bone marrow (BM) is low in low-risk MDS subtypes, and is high in high-risk MDS subtypes. However, the role of WT1 in the differential diagnosis between MDS and other diseases showing cytopenia has not been fully addressed. The present study evaluated whether WT1 expression level can assist in the differential diagnosis of MDS from other cytopenias. Methods The amount of WT1 message was evaluated among 56 MDS patients and 47 patients with cytopenia for various other reasons (cytopenia VR) at the Nagasaki University Hospital. Results The level of WT1 was significantly related to the percentage of blasts in BM among MDS cases, and the type of French-American-British classification of MDS; refractory anemia (RA) cases showed significantly lower WT1 level than patients with RA with excess blasts. WT1 level was significantly related to the prognostic risk categories of MDS by the International Prognostic Scoring System (IPSS) and the revised IPSS. Although the blast percentage in the BM of RA and cytopenia VR were both less than 5%, there was a significant difference in the level of WT1 between MDS and cytopenia VR. Conclusion WT1 might be a good marker to differentiate low blast percentage MDS and cytopenia VR. | |||||
書誌情報 |
Internal Medicine 巻 54, 号 5, p. 445-451, 発行日 2015-03-01 |
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出版者 | ||||||
出版者 | 日本内科学会 | |||||
出版者別言語 | ||||||
Japanese Society of Internal Medicine | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09182918 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13497235 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2169/internalmedicine.54.3123 | |||||
権利 | ||||||
権利情報 | c 2015 The Japanese Society of Internal Medicine. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Internal Medicine, 54(5), pp.445-451; 2015 |