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Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans
http://hdl.handle.net/10069/35334
http://hdl.handle.net/10069/3533402777440-0903-4a4a-9083-61b30fc80e6a
名前 / ファイル | ライセンス | アクション |
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MarDru13_1084.pdf (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-05-15 | |||||
タイトル | ||||||
タイトル | Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adjuvant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dendritic cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fucoidans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neutrophils | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NK cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zhang, Wei
× Zhang, Wei× Oda, Tatsuya× Yu, Qing× Jin, Jun-O |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, such as promoting activation of dendritic cells (DCs), natural killer (NK) cells and T cells, and enhancing anti-viral and anti-tumor responses. However, the immune-modulatory effect of fucoidan from different seaweed extracts has not been thoroughly analyzed and compared. We analyzed fucoidans obtained from Ascophyllum nodosum (A. nodosum), Macrocystis pyrifera (M. pyrifera), Undaria pinnatifida (U. pinnatifida) and Fucus vesiculosus (F. vesiculosus) for their effect on the apoptosis of human neutrophils, activation of mouse NK cells, maturation of spleen DCs, proliferation and activation of T cells, and the adjuvant effect in vivo. Fucoidans from M. pyrifera and U. pinnatifida strongly delayed human neutrophil apoptosis at low concentration, whereas fucoidans from A. nodosum and F. vesiculosus delayed human neutrophil apoptosis at higher concentration. Moreover, fucoidan from M. pyrifera promoted NK cell activation and cytotoxic activity against YAC-1 cells. In addition, M. pyrifera fucoidan induced the strongest activation of spleen DCs and T cells and ovalbumin (OVA) specific immune responses compared to other fucoidans. These data suggest that fucoidan from M. pyrifera can be potentially useful as a therapeutic agent for infectious diseases, cancer and an effective adjuvant for vaccine. | |||||
書誌情報 |
Marine Drugs 巻 13, 号 3, p. 1084-1104, 発行日 2015-02-19 |
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出版者 | ||||||
出版者 | Multidisciplinary Digital Publishing Institute (MDPI) | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16603397 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/md13031084 | |||||
権利 | ||||||
権利情報 | c 2015 by the authors; licensee MDPI, Basel, Switzerland. | |||||
権利 | ||||||
権利情報 | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Marine Drugs, 13(3), pp.1084-1104; 2015 |