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Antigen-driven focal inflammatory death of malaria liver stages
http://hdl.handle.net/10069/35381
http://hdl.handle.net/10069/35381fd858198-629b-4ce2-a8c4-22d5a47ad837
名前 / ファイル | ライセンス | アクション |
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Fmicb6_47.pdf (471.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-05-25 | |||||
タイトル | ||||||
タイトル | Antigen-driven focal inflammatory death of malaria liver stages | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD8+ T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cooperative behavior | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | In vivo imaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inflammatory infiltrate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Bayarsaikhan, Ganchimeg
× Bayarsaikhan, Ganchimeg× Akbari, Masoud× Yui, Katsuyuki× Amino, Rogerio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Multiple immunizations using live irradiated sporozoites, the infectious plasmodial stage delivered into the host skin during a mosquito bite, can elicit sterile immunity to malaria. CD8+ T cells seem to play an essential role in this protective immunity, since their depletion consistently abolishes sterilizing protection in several experimental models. So far, only a few parasite antigens are known to induce CD8+ T cell-dependent protection, but none of them can reach the levels of protection afforded by live attenuated parasites. Systematic attempts to identify novel antigens associated with this efficient cellular protection were so far unsuccessful. In addition, the precise mechanisms involved in the recognition and elimination of parasitized hepatocytes in vivo by CD8+ T cells still remain obscure. Recently, it has been shown that specific effector CD8+ T cells, after recognition of parasitized hepatocytes, recruit specific and non-specific activated CD8+ T cells to the site of infection, resulting in the formation of cellular clusters around and in the further elimination of intracellular parasites. The significance of this finding is discussed in the perspective of a general mechanism of antigen-dependent focalized inflammation and its consequences for the elimination of malaria liver stages. | |||||
書誌情報 |
Frontiers in Microbiology 巻 6, p. 47, 発行日 2015-02-04 |
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出版者 | ||||||
出版者 | Frontiers Media S. A. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664302X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fmicb.2015.00047 | |||||
権利 | ||||||
権利情報 | c 2015 Bayarsaikhan, Akbari, Yui and Amino. | |||||
権利 | ||||||
権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Frontiers in Microbiology, 6, 47; 2015 |