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Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi
http://hdl.handle.net/10069/39595
http://hdl.handle.net/10069/39595d478cd0c-41f7-4937-9615-71a812fdba0b
名前 / ファイル | ライセンス | アクション |
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ISYK1194_Odsuren.pdf (1.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-12-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD4+ T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-27 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-10 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protective immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunological memory | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
ODSUREN, Sukhbaatar
× ODSUREN, Sukhbaatar |
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著者別名 | ||||||
姓名 | オドスレン, スフバータル | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | IL-27, a regulatory cytokine, plays critical roles in the prevention of immunopathology during Plasmodium infection. We examined these roles in the immune responses against Plasmodium chabaudi infection using the Il-27ra?/? mice. While IL-27 was expressed at high levels during the early phase of the infection, enhanced CD4+ T cell function and reduction in parasitemia were observed mainly during the chronic phase in the mutant mice. In mice infected with P. chabaudi and cured with drug, CD4+ T cells in the Il-27ra?/? mice exhibited enhanced CD4+ T-cell responses, indicating the inhibitory role of IL-27 on the protective immune responses. To determine the role of IL-27 in detail, we performed CD4+ T-cell transfer experiments. The Il-27ra?/? and Il27p28?/? mice were first infected with P. chabaudi and then cured using drug treatment. Plasmodium-antigen primed CD4+ T cells were prepared from these mice and transferred into the recipient mice, followed by infection with the heterologous parasite P. berghei ANKA. Il-27ra?/? CD4+ T cells in the infected recipient mice did not produce IL-10, indicating that IL-10 production by primed CD4+ T cells is IL-27 dependent. Il27p28?/? CD4+ T cells that were primed in the absence of IL-27 exhibited enhanced recall responses during the challenge infection with P. berghei ANKA, implying that IL-27 receptor signaling during the primary infection affects recall responses in the long-term via the regulation of the memory CD4+ T cell generation. These features highlighted direct and time-transcending roles of IL-27 in the regulation of immune responses against chronic infection with Plasmodium parasites. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1194号 学位授与年月日:令和元年12月4日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Odsuren Sukhbaatar, Daisuke Kimura, Mana Miyakoda, Sayuri Nakamae, Kazumi Kimura, Hiromitsu Hara, Hiroki Yoshida, Shin-Ichi Inoue, Katsuyuki Yui | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Parasitology International, 74, 101994; 2020 | |||||
書誌情報 |
Parasitology International 巻 74, p. 101994, 発行日 2019-12-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13835769 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.parint.2019.101994 | |||||
権利 | ||||||
権利情報 | c 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | Plasmodium chabaudi慢性感染における特異的CD4+ T細胞の活性化とIL-10産生は、IL-27により制御される | |||||
出版者 | ||||||
出版者 | Elsevier B.V. | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/39584 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-12-04 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1194号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2019-12-04) |