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Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model
http://hdl.handle.net/10069/35448
http://hdl.handle.net/10069/354489634af0b-70e7-4734-bdf0-eeb405a9dd31
名前 / ファイル | ライセンス | アクション |
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ActaBio19_112.pdf (932.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-07-01 | |||||
タイトル | ||||||
タイトル | Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cavitation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Doxorubicin loaded microbubbles | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Theranostics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ultrasound | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Abdalkader, Rodi
× Abdalkader, Rodi× Kawakami, Shigeru× Unga, Johan× Suzuki, Ryo× Maruyama, Kazuo× Yamashita, Fumiyoshi× Hashida, Mitsuru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, a novel phospholipid-based microbubble formulation containing doxorubicin and perfluoropropane gas (DLMB) was developed. The DLMBs were prepared by mechanical agitation of a phospholipid dispersion in the presence of perfluoropropane (PFP) gas. An anionic phospholipid, distearoyl phosphatidylglycerol (DSPG) was selected to load doxorubicin in the microbubbles by means of electrostatic interaction. The particle size, zeta potential, echogenicity and stability of the DLMBs were measured. Drug loading was ?92%. The potential of the DLMBs for use as a theranostic modality was evaluated in tumor bearing mice. Gas chromatography analysis of PFP showed significant enhancement of PFP retention when doxorubicin was used at concentrations of 10-82% equivalent to DSPG. The inhibitory effects on the proliferation of B16BL6 melanoma murine cells in vitro were enhanced using a combination of ultrasound (US) irradiation and DLMBs. Moreover, in vivo DLMBs in combination with (US) irradiation significantly inhibited the growth of B16BL6 melanoma tumor in mice. Additionally, US echo imaging showed high contrast enhancement of the DLMBs in the tumor vasculature. These results suggest that DLMBs could serve as US triggered carriers of doxorubicin as well as tumor imaging agents in cancer therapy. | |||||
書誌情報 |
Acta Biomaterialia 巻 19, p. 112-118, 発行日 2015-06 |
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出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17427061 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.actbio.2015.03.014 | |||||
権利 | ||||||
権利情報 | c 2015 Acta Materialia Inc. Published by Elsevier Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Biomaterialia, 19, pp.112-118; 2015 |