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IL-12 Inhibits Lipopolysaccharide Stimulated Osteoclastogenesis in Mice
http://hdl.handle.net/10069/35498
http://hdl.handle.net/10069/354986bb57c17-b8eb-4f27-8a79-33fe92a037cd
名前 / ファイル | ライセンス | アクション |
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JIR2015_214878.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-06-29 | |||||
タイトル | ||||||
タイトル | IL-12 Inhibits Lipopolysaccharide Stimulated Osteoclastogenesis in Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshimatsu, Masako
× Yoshimatsu, Masako× Kitaura, Hideki× Fujimura, Yuji× Kohara, Haruka× Morita, Yukiko× Yoshida, Noriaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lipopolysaccharide (LPS) is related to osteoclastogenesis in osteolytic diseases. Interleukin-(IL-) 12 is an inflammatory cytokine that plays a critical role in host defense. In this study, we investigated the effects of IL-12 on LPS-induced osteoclastogenesis. LPS was administered with or without IL-12 into the supracalvariae of mice, and alterations in the calvarial suture were evaluated histochemically. The number of osteoclasts in the calvarial suture and the mRNA level of tartrate-resistant acid phosphatase (TRAP), an osteoclast marker, were lower in mice administered LPS with IL-12 than in mice administered LPS alone. The serum level of tartrate-resistant acid phosphatase 5b (TRACP 5b), a bone resorption marker, was also lower in mice administered LPS with IL-12 than in mice administered LPS alone. These results revealed that IL-12 might inhibit LPS-induced osteoclastogenesis and bone resorption. In TdT-mediated dUTP-biotin nick end-labeling (TUNEL) assays, apoptotic changes in cells were recognized in the calvarial suture in mice administered LPS with IL-12. Furthermore, the mRNA levels of both Fas and FasL were increased in mice administered LPS with IL-12. Taken together, the findings demonstrate that LPS-induced osteoclastogenesis is inhibited by IL-12 and that this might arise through apoptotic changes in osteoclastogenesis-related cells induced by Fas/FasL interactions. | |||||
書誌情報 |
Journal of Immunology Research 巻 2015, p. 1-8, 発行日 2015 |
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出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 23148861 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 23147156 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2015/214878 | |||||
権利 | ||||||
権利情報 | c 2015 Masako Yoshimatsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Immunology Research, 2015, 214878; 2015 |