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However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences. Among epigenetic modifications, histone acetylation leads to the transcriptional activation of genes. Recent studies indicate that histone acetylation is involved in the progression of fibrosis. Therefore, we examined the effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on the progression of peritoneal fibrosis in mice. Methods: Peritoneal fibrosis was induced by the injection of chlorhexidine gluconate (CG) into the peritoneal cavity of mice every other day for 3 weeks. SAHA, or a dimethylsulfoxide and saline vehicle, was administered subcutaneously every day from the start of the CG injections for 3 weeks. Morphologic peritoneal changes were assessed by Masson’s trichrome staining, and fibrosis-associated factors were assessed by immunohistochemistry. 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SAHA Suppresses Peritoneal Fibrosis in Mice
http://hdl.handle.net/10069/35643
http://hdl.handle.net/10069/35643ff4e5d63-9aa5-4159-b225-65b185f457ce
名前 / ファイル | ライセンス | アクション |
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PDI35_246.pdf (877.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-06-01 | |||||
タイトル | ||||||
タイトル | SAHA Suppresses Peritoneal Fibrosis in Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chlorhexidine gluconate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Histone deacetylase inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SAHA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Suberoylanilide hydroxamic acid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Io, Kumiko
× Io, Kumiko× Nishino, Tomoya× Obata, Yoko× Kitamura, Mineaki× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Long-term peritoneal dialysis causes peritoneal fibrosis in submesothelial areas. However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences. Among epigenetic modifications, histone acetylation leads to the transcriptional activation of genes. Recent studies indicate that histone acetylation is involved in the progression of fibrosis. Therefore, we examined the effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on the progression of peritoneal fibrosis in mice. Methods: Peritoneal fibrosis was induced by the injection of chlorhexidine gluconate (CG) into the peritoneal cavity of mice every other day for 3 weeks. SAHA, or a dimethylsulfoxide and saline vehicle, was administered subcutaneously every day from the start of the CG injections for 3 weeks. Morphologic peritoneal changes were assessed by Masson’s trichrome staining, and fibrosis-associated factors were assessed by immunohistochemistry. Results: In CG-injected mice, a marked thickening of the submesothelial compact zone was observed. In contrast, the administration of SAHA suppressed the progression of submesothelial thickening and type III collagen accumulation in CG-injected mice. The numbers of fibroblast-specific protein-1?positive cells and α-smooth muscle actin α?positive cells were significantly decreased in the CG + SAHA group compared to that of the CG group. The level of histone acetylation was reduced in the peritoneum of the CG group, whereas it was increased in the CG +SAHA group. Conclusions: Our results indicate that SAHA can suppress peritoneal thickening and fibrosis in mice through up-regulation of histone acetylation. These results suggest that SAHA may have therapeutic potential for treating peritoneal fibrosis. | |||||
書誌情報 |
Peritoneal Dialysis International 巻 35, 号 3, p. 246-258, 発行日 2015-05 |
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出版者 | ||||||
出版者 | Multimed Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08968608 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17184304 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3747/pdi.2013.00089 | |||||
権利 | ||||||
権利情報 | c 2015 International Society for Peritoneal Dialysis | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Peritoneal Dialysis International, 35(3), pp.246-258; 2015 |