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Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models
http://hdl.handle.net/10069/35660
http://hdl.handle.net/10069/35660ddf88039-2fd0-44e8-8a76-fc9032954749
名前 / ファイル | ライセンス | アクション |
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AMS4_211.pdf (544.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-07-22 | |||||
タイトル | ||||||
タイトル | Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dai-kenchu-to (DKT) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Herbal medicine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver cirrhosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver regeneration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Portal blood flow | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Muraoka, Izumi
× Muraoka, Izumi× Takatsuki, Mitsuhisa× Soyama, Akihiko× Yamaguchi, Izumi× Tanaka, Shiro× Tanaka, Takayuki× Kinoshita, Ayaka× Hara, Takanobu× Kuroki, Tamotsu× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: To clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound. Methods: Normal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a DKT-LC 90 mg/kg administered group and Control-LC. The PBF was measured after the administration of either DKT or water for 60 min by laser Doppler flowmetry system. Results: The PBF in the DKT 90 increased approximately 10 min after DKT was administrated, and elevated levels were maintained for approximately 10 min. A comparison of the increase in PBF by the calculating the area under the curve (AUC) revealed that flow was significantly higher in the DKT 90 compared to either the control or the DKT 270 (p < 0.05). The cirrhotic liver group showed stable PBF in both the DKT-LC and Control-LC. The AUC, revealed no significant difference between the DKT-LC and Control-LC. Discussion: DKT induced an increase in PBF in normal livers; however, its effects were insufficient to increase PBF in the cirrhotic livers. No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract. Conclusion: We suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction. | |||||
書誌情報 |
Annals of Medicine and Surgery 巻 4, 号 3, p. 211-214, 発行日 2015-09 |
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出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20490801 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.amsu.2015.05.008 | |||||
権利 | ||||||
権利情報 | c 2015 Published by Elsevier Ltd on behalf of IJS Publishing Group Limited. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Annals of Medicine and Surgery, 4(3), pp.211-214; 2015 |