WEKO3
アイテム
{"_buckets": {"deposit": "d165f899-58fa-4fbc-8b14-e0360d5f035b"}, "_deposit": {"created_by": 2, "id": "4532", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "4532"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00004532", "sets": ["28"]}, "author_link": ["18042", "18043", "18046", "18041", "18040", "18045", "18044"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "732", "bibliographicPageStart": "725", "bibliographicVolumeNumber": "28", "bibliographic_titles": [{"bibliographic_title": "BioMetals"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Cobalt protoporphyrin (CoPP) is a metallo-protoporphyrin that works as a powerful inducer of heme oxigenase-1 (HO-1) in various tissues and cells. Our recent studies have demonstrated that induction of HO-1 by several reagents inhibited differentiation and activation of osteoclasts (OCLs), which are multinucleated bone resorbing cells. However, the effects of CoPP on osteoclastogenesis remain to be elucidated. In this study, we report that CoPP inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced OCL formation in a dose dependent manner. Importantly, CoPP had little cytotoxicity, but rather enhanced cell proliferation of OCLs. CoPP suppressed the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1) as well as those of OCLs markers such as Src and cathepsin K, which are transcriptionally regulated by NFATc1 in mature OCLs. Western blot analyses also showed that CoPP abolished RANKL-stimulated phosphorylation of several major signaling pathways such as IκB, Akt, ERK, JNK and p38 MAPKs in OCL precursor cells. Thus, our results show that CoPP represses osteoclastogenesis through blocking multiple signaling pathways.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "BioMetals, 28(4), pp.725-732; 2015", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Netherlands"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s10534-015-9861-9", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2015 Springer Science+Business Media New York."}, {"subitem_rights": "The final publication is available at link.springer.com"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09660844", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "15728773", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yashima, Yuka"}], "nameIdentifiers": [{"nameIdentifier": "18040", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okamoto, Kuniaki"}], "nameIdentifiers": [{"nameIdentifier": "18041", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakai, Eiko"}], "nameIdentifiers": [{"nameIdentifier": "18042", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwatake, Mayumi"}], "nameIdentifiers": [{"nameIdentifier": "18043", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuma, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "18044", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishishita, Kazuhisa"}], "nameIdentifiers": [{"nameIdentifier": "18045", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukuba, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "18046", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "BioMet28_725.pdf", "filesize": [{"value": "797.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 797500.0, "url": {"label": "BioMet28_725.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/4532/files/BioMet28_725.pdf"}, "version_id": "d63e03b8-ca8c-4a67-ae82-56abc34c66b5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cobalt protoporphyrin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hemeoxigenase-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Osteoclasts", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RANKL", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways"}]}, "item_type_id": "2", "owner": "2", "path": ["28"], "permalink_uri": "http://hdl.handle.net/10069/35664", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-09-01"}, "publish_date": "2016-09-01", "publish_status": "0", "recid": "4532", "relation": {}, "relation_version_is_last": true, "title": ["Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways"], "weko_shared_id": -1}
Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways
http://hdl.handle.net/10069/35664
http://hdl.handle.net/10069/356649f140177-9d61-4a5e-98ea-a4b95a279d25
名前 / ファイル | ライセンス | アクション |
---|---|---|
BioMet28_725.pdf (797.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-09-01 | |||||
タイトル | ||||||
タイトル | Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cobalt protoporphyrin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hemeoxigenase-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoclasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yashima, Yuka
× Yashima, Yuka× Okamoto, Kuniaki× Sakai, Eiko× Iwatake, Mayumi× Fukuma, Yutaka× Nishishita, Kazuhisa× Tsukuba, Takayuki |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cobalt protoporphyrin (CoPP) is a metallo-protoporphyrin that works as a powerful inducer of heme oxigenase-1 (HO-1) in various tissues and cells. Our recent studies have demonstrated that induction of HO-1 by several reagents inhibited differentiation and activation of osteoclasts (OCLs), which are multinucleated bone resorbing cells. However, the effects of CoPP on osteoclastogenesis remain to be elucidated. In this study, we report that CoPP inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced OCL formation in a dose dependent manner. Importantly, CoPP had little cytotoxicity, but rather enhanced cell proliferation of OCLs. CoPP suppressed the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1) as well as those of OCLs markers such as Src and cathepsin K, which are transcriptionally regulated by NFATc1 in mature OCLs. Western blot analyses also showed that CoPP abolished RANKL-stimulated phosphorylation of several major signaling pathways such as IκB, Akt, ERK, JNK and p38 MAPKs in OCL precursor cells. Thus, our results show that CoPP represses osteoclastogenesis through blocking multiple signaling pathways. | |||||
書誌情報 |
BioMetals 巻 28, 号 4, p. 725-732, 発行日 2015-08 |
|||||
出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09660844 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15728773 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10534-015-9861-9 | |||||
権利 | ||||||
権利情報 | c 2015 Springer Science+Business Media New York. | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BioMetals, 28(4), pp.725-732; 2015 |