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Exopeptidases and gingipains in Porphyromonas gingivalis as prerequisites for its amino acid metabolism
http://hdl.handle.net/10069/36140
http://hdl.handle.net/10069/3614061e38a3f-90b0-472c-8f10-e6d40a5b1cda
名前 / ファイル | ライセンス | アクション |
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JDSR52_22.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-01-25 | |||||
タイトル | ||||||
タイトル | Exopeptidases and gingipains in Porphyromonas gingivalis as prerequisites for its amino acid metabolism | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Periodontitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amino acid metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dipeptidyl peptidase (DPP) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Exopeptidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Porphyromonas gingivalis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nemoto, Takayuki K.
× Nemoto, Takayuki K.× Ohara-Nemoto, Yuko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Porphyromonas gingivalis, an asaccharolytic bacterium, utilizes amino acids as energy and carbon sources. Since amino acids are incorporated into the bacterial cells mainly as di- and tri-peptides, exopeptidases including dipeptidyl-peptidase (DPP) and tripeptidyl-peptidase are considered to be prerequisite components for their metabolism. We recently discovered DPP11, DPP5, and acylpeptidyl oligopeptidase in addition to previously reported DPP4, DPP7, and prolyl tripeptidyl peptidase A. DPP11 is a novel enzyme specific for acidic P1 residues (Asp and Glu) and distributed ubiquitously in eubacteria, while DPP5 is preferential for the hydrophobic P1 residue and the first entity identified in prokaryotes. Recently, acylpeptidyl oligopeptidase with a preference for hydrophobic P1 residues was found to release N-terminally blocked di- and tri-peptides. Furthermore, we also demonstrated that gingipains R and K contribute to P1-basic dipeptide production. These observations implicate that most, if not all, combinations of di- and tri-peptides are produced from extracellular oligopeptides even with an N-terminal modification. Here, we review P. gingivalis exopeptidases mainly in regard to their enzymatic characteristics. These exopeptidases with various substrate specificities benefit P. gingivalis for obtaining energy and carbon sources from the nutritionally limited subgingival environment. | |||||
書誌情報 |
Japanese Dental Science Review 巻 52, 号 1, p. 22-29, 発行日 2016-02 |
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出版者 | ||||||
出版者 | 日本歯科医学会 | |||||
出版者別言語 | ||||||
Japanese Association for Dental Science | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18827616 | |||||
権利 | ||||||
権利情報 | c 2015 Japanese Association for Dental Science. | |||||
権利 | ||||||
権利情報 | This is an openaccess article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Dental Science Review, 52(1), pp.22-29; 2016 |