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Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese
http://hdl.handle.net/10069/35818
http://hdl.handle.net/10069/35818b9450a37-4401-4467-97de-e8b29449abd0
名前 / ファイル | ライセンス | アクション |
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Athe242_433.pdf (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-09-04 | |||||
タイトル | ||||||
タイトル | Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endothelial function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reference value | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reliability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Standardization | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tomiyama, Hirofumi
× Tomiyama, Hirofumi× Kohro, Takahide× Higashi, Yukihito× Takase, Bonpei× Suzuki, Toru× Ishizu, Tomoko× Ueda, Shinichiro× Yamazaki, Tsutomu× Furumoto, Tomoo× Kario, Kazuomi× Inoue, Teruo× Koba, Shinji× Watanabe, Kentaro× Takemoto, Yasuhiko× Hano, Takuzo× Sata, Masataka× Ishibashi, Yutaka× Node, Koichi× Maemura, Koji× Ohya, Yusuke× Furukawa, Taiji× Ito, Hiroshi× Ikeda, Hisao× Yamashina, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aims: For the standardization of flow-mediated vasodilatation (FMD) assessment as a clinical tool, validation of its reliability across multiple institutions and the establishment of normal/reference values based on reliable data from multiple institutions are needed. Methods and results: In Study 1, assessment of FMD (scan recording and analysis) using an ultrasonographic semi-automatic measuring system (sFMD) was conducted at 18 participating institutions (sFMD-INST) (n = 981). All of the brachial arterial scans were also analyzed at a core laboratory (sFMD-COLB). After 111 subjects with inadequate sFMD recordings were excluded (n = 880), the correlation between the sFMD-INST and sFMD-COLB improved from R = 0.725 to R = 0.838 (p < 0.001). In Study 2, based on good-quality sFMD data obtained from 6660 subjects without cardiovascular disease (CVD) and 729 subjects with CVD from 27 institutions, reference values of sFMD are proposed by the Framingham risk score (FRS)-based risk categories and according to gender and age. The receiver-operating characteristic curve analysis revealed a significant power of sFMD values in reference ranges to discriminate between subjects with and without CVD (e.g., area under curve = 0.64 in the FRS-low risk group). Conclusions: When the analysis was limited to cases with clear sFMD recordings, the reliability of the sFMD assessment (scan and its analysis) conducted in individual institutions appeared to be acceptable. Reference sFMD values (lower cuff occlusion) for the Japanese population are proposed based on reliable data derived from multiple institutions, and the reference values may identify patients without advanced vascular damage. | |||||
書誌情報 |
Atherosclerosis 巻 242, 号 2, p. 433-442, 発行日 2015-10 |
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出版者 | ||||||
出版者 | Elsevier Ireland Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00219150 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.atherosclerosis.2015.08.001 | |||||
権利 | ||||||
権利情報 | c 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Atherosclerosis, 242(2), pp.433-442; 2015 |