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Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats
http://hdl.handle.net/10069/35834
http://hdl.handle.net/10069/35834bb37921b-0a00-47fa-8a21-4172cc4b10a5
名前 / ファイル | ライセンス | アクション |
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JDR2015_675201.pdf (2.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-09-11 | |||||
タイトル | ||||||
タイトル | Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Lin, Wenting
× Lin, Wenting× Wang, Wenxiang× Liao, Dongdong× Chen, Damiao× Zhu, Pingping× Cai, Guoxi× Kiyoshi, Aoyagi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study investigated the effects of polysaccharides from Enteromorpha prolifera (PEP) on glucose metabolism in a rat model of diabetes mellitus (DM). PEP (0, 150, 300, and 600 mg/kg) was administered intragastrically to rats for four weeks. After treatment, fasting blood glucose (FBG) and insulin (INS) levels were measured, and the insulin sensitivity index (ISI) was calculated. The morphopathological changes in the pancreas were observed. Serum samples were collected to measure the oxidant-antioxidant status. The mRNA expression levels of glucokinase (GCK) and insulin receptor (InsR) in liver tissue and glucose transporter type 4 (GLUT-4) and adiponectin (APN) in adipose tissue were determined. Compared with the model group, the FBG and INS levels were lower, the ISI was higher, and the number of islet β-cells was significantly increased in all the PEP groups. In the medium- and high-dose PEP groups, MDA levels decreased, and the enzymatic activities of SOD and GSH-Px increased. The mRNA expression of InsR and GCK increased in all the PEP groups; APN mRNA expression increased in the high-dose PEP group, and GLUT-4 mRNA expression increased in adipose tissue. These findings suggest that PEP is a potential therapeutic agent that can be utilized to treat DM. | |||||
書誌情報 |
Journal of Diabetes Research 巻 2015, p. 1-12, 発行日 2015 |
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出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 23146745 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 23146753 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2015/675201 | |||||
権利 | ||||||
権利情報 | c 2015 Wenting Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Diabetes Research, 2015, 675201; 2015 |