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Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system
http://hdl.handle.net/10069/35850
http://hdl.handle.net/10069/358500037db2c-6b70-4122-bc64-2cd7a7005fa7
名前 / ファイル | ライセンス | アクション |
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JPP64_848.pdf (379.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-09-25 | |||||
タイトル | ||||||
タイトル | Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatic disposition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | indocyanine green | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver perfusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phenolsulfonphthalein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | therapeutic hypothermia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyamoto, Hirotaka
× Miyamoto, Hirotaka× Miyake, Hideaki× Yoshikawa, Naoki× Hirata, Haruna× Ohwaki, Yuichi× Fumoto, Shintaro× Sasaki, Hitoshi× Nakamura, Junzo× Nishida, Koyo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives The aim of this study was to determine the factor changing the hepatic disposition of a drug during hypothermia using a rat liver perfusion system. Methods The livers of male Wistar rats were perfused at 37, 32 or 28°C in the single-pass mode. Venous outflow dilution patterns and biliary excretion rate patterns of phenolsulfonphthalein (PSP), indocyanine green (ICG) and fluorescein isothiocyanate (FITC)-dextran (FD-4, MW 4400) after the injection of a bolus into the perfused rat liver were analysed based on statistical moment theory. Key findings The first-pass extraction ratio (E h) of PSP was significantly decreased at 32 and 28°C compared with 37°C. The biliary recovery of PSP and its conjugate was decreased and the biliary excretion was kept at a high concentration and was prolonged by low perfusion temperatures. ICG was almost extracted by a single-pass through the liver even at 32 and 28°C. The biliary recovery of ICG was significantly decreased at low temperature. Although the distribution volume of FD-4 as a vascular reference was not changed by perfusion temperature, the E h of FD-4 was decreased at 28°C although not markedly. Conclusion The change in hepatic disposition of a drug at low perfusion temperatures differed according to disposition processes under hypothermia. | |||||
書誌情報 |
Journal of Pharmacy and Pharmacology 巻 64, 号 6, p. 848-854, 発行日 2012-06 |
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出版者 | ||||||
出版者 | Pharmaceutical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00223573 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.2042-7158.2012.01478.x | |||||
権利 | ||||||
権利情報 | c 2012 Royal Pharmaceutical Society | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Journal of Pharmacy and Pharmacology, 64(6), pp.848-854; 2012, which has been published in final form at http://dx.doi.org/10.1111/j.2042-7158.2012.01478.x This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmacy and Pharmacology, 64(6), pp.848-854; 2012 |