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A Single Amino Acid Substitution in the NS2A Protein of Japanese Encephalitis Virus Affects Virus Propagation In Vitro but Not In Vivo
http://hdl.handle.net/10069/35864
http://hdl.handle.net/10069/358647610d03f-7fa5-4cc4-9c64-e16590b61f7f
名前 / ファイル | ライセンス | アクション |
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JV89_6126.pdf (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-01-01 | |||||
タイトル | ||||||
タイトル | A Single Amino Acid Substitution in the NS2A Protein of Japanese Encephalitis Virus Affects Virus Propagation In Vitro but Not In Vivo | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takamatsu, Yuki
× Takamatsu, Yuki× Morita, Kouichi× Hayasaka, Daisuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We identified a unique amino acid of NS2A113, phenylalanine, that affects the efficient propagation of two Japanese encephalitis virus strains, JaTH160 and JaOArS982, in neuroblastoma Neuro-2a cells but not in cell lines of extraneural origin. This amino acid did not affect viral loads in the brain or survival curves in mice. These findings suggest that virus propagation in vitro may not reflect the level of virus neuroinvasiveness in vivo. | |||||
書誌情報 |
Journal of Virology 巻 89, 号 11, p. 6126-6130, 発行日 2015-06 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022538X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10985514 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/JVI.00370-15 | |||||
権利 | ||||||
権利情報 | c 2015, American Society for Microbiology | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Virology, 89(11), pp.6126-6130; 2015 |